These authors contributed equally to this work.
Portal Venous Versus Systemic Venous Drainage of Pancreas Grafts: Impact on Long-Term Results
Article first published online: 4 NOV 2011
©Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 12, Issue 1, pages 226–232, January 2012
How to Cite
Bazerbachi, F., Selzner, M., Marquez, M. A., Norgate, A., Aslani, N., McGilvray, I. D., Schiff, J. and Cattral, M. S. (2012), Portal Venous Versus Systemic Venous Drainage of Pancreas Grafts: Impact on Long-Term Results. American Journal of Transplantation, 12: 226–232. doi: 10.1111/j.1600-6143.2011.03756.x
- Issue published online: 13 JAN 2012
- Article first published online: 4 NOV 2011
- Received 13 April 2011, revised 08 August 2011 and accepted for publication 15 August 2011
- Long-term outcome;
- synchronous pancreas–kidney transplantation;
- venous drainage
Portal venous (PV) and systemic venous (SV) drainage methods are used in pancreas transplantation. The impact of the reconstruction technique on long-term outcome remains unclear. We compared the efficacy and side effects of both methods in 192 recipients who received synchronous pancreas kidney transplants between November 1995 and November 2007. SV and PV drainage were used in 147 and 45 cases, respectively. Pancreas function was determined by hemoglobin A1c levels and annual oral glucose tolerance test. Serum creatinine assessed kidney function. Serum lipid (low-density lipoprotein, high-density lipoprotein and cholesterol) levels and body mass index were measured annually. Patient and graft survival were calculated by log-rank analysis. Pancreas survival for SV versus PV patients was similar after 5 years (81.8% vs. 75.5%) and 10 years (65.1% vs. 60%; p = NS). Similarly, no difference was detected between the groups regarding kidney survival after 5 years (92.9% vs. 84.4%) and 10 years (81.6% vs. 75.5%; p = NS). Patient survival did not differ at 5 years (94.3% vs. 88.8%) and 10 years (85.1% vs. 84.4%; p = NS). Pancreas and kidney function and the lipid profiles were similar in both groups. SV and PV drainage of pancreas grafts offer similar long-term graft survival and function and choice of method should remain the preference of the surgeon.