Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8+ Memory T Cells
Article first published online: 22 SEP 2011
©Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 12, Issue 1, pages 69–80, January 2012
How to Cite
Kitchens, W. H., Haridas, D., Wagener, M. E., Song, M., Kirk, A. D., Larsen, C. P. and Ford, M. L. (2012), Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8+ Memory T Cells. American Journal of Transplantation, 12: 69–80. doi: 10.1111/j.1600-6143.2011.03762.x
- Issue published online: 13 JAN 2012
- Article first published online: 22 SEP 2011
- Received 16 March 2011, revised 01 August 2011 and accepted for publication 17 August 2011
Table S1: Combined costimulatory/integrin blockade prolongs graft survival even against a donor-specific CD8+ T-cell response
Figure S1: Integrin upregulation on memory T cells.
Figure S2: High memory OT-I frequency after serial LM-OVA infection prevents graft survival prolongation with combined integrin/costimulatory blockade.
Figure S3: Dual costimulatory/integrin blockade does not inhibit donor-reactive memory CD8+ T-cell expansion and accumulation compared to CoB alone.
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