These authors have contributed equally to the work.
Donor Age-Specific Injury and Immune Responses
Article first published online: 4 NOV 2011
©Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 12, Issue 1, pages 38–42, January 2012
How to Cite
Oberhuber, R., Ge, X. and Tullius, S. G. (2012), Donor Age-Specific Injury and Immune Responses. American Journal of Transplantation, 12: 38–42. doi: 10.1111/j.1600-6143.2011.03798.x
- Issue published online: 13 JAN 2012
- Article first published online: 4 NOV 2011
- Received 21 April 2011, revised 29 August 2011 and accepted for publication 30 August 2011
- injury and repair;
Utilization rates of organs from elderly donors have shown the highest proportional increase during the last decade. Clinical reports support the concept of transplanting older organs. However, the engraftment of such organs has been linked to accelerated immune responses based on ageing changes per se and a proinflammatory environment subsequent to compromised injury and repair mechanism. We analyzed the clinical consequences of transplanting older donor organs and present mechanistic aspects correlating age, injury repair and effects on host immunoresponsiveness.