Meeting Report

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Banff 2011 Meeting Report: New Concepts in Antibody-Mediated Rejection

  1. M. Mengel1,2,*,
  2. B. Sis1,2,
  3. M. Haas3,
  4. R. B. Colvin4,
  5. P. F. Halloran2,
  6. L. C. Racusen5,
  7. K. Solez1,
  8. L. Cendales6,
  9. A. J. Demetris7,
  10. C. B. Drachenberg8,
  11. C. F. Farver9,
  12. E. R. Rodriguez9,
  13. W. D. Wallace10,
  14. D. Glotz11,
  15. as the Banff meeting report writing committee

Article first published online: 2 FEB 2012

DOI: 10.1111/j.1600-6143.2011.03926.x

Issue

American Journal of Transplantation

American Journal of Transplantation

Volume 12, Issue 3, pages 563–570, March 2012

Additional Information

How to Cite

Mengel, M., Sis, B., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Cendales, L., Demetris, A. J., Drachenberg, C. B., Farver, C. F., Rodriguez, E. R., Wallace, W. D., Glotz, D. and as the Banff meeting report writing committee (2012), Banff 2011 Meeting Report: New Concepts in Antibody-Mediated Rejection. American Journal of Transplantation, 12: 563–570. doi: 10.1111/j.1600-6143.2011.03926.x

Author Information

  1. 1

    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada

  2. 2

    Department of Medicine, Alberta Transplant Applied Genomics Centre, Division of Nephrology & Immunology, University of Alberta, Edmonton, Canada

  3. 3

    Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

  4. 4

    Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA

  5. 5

    Department of Pathology, Johns Hopkins University, Baltimore, MD

  6. 6

    Emory Transplant Center, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, GA

  7. 7

    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA

  8. 8

    Department of Pathology, University of Maryland, Baltimore, MD

  9. 9

    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH

  10. 10

    Department of Laboratory Medicine and Pathology, University of California, Los Angeles, CA

  11. 11

    Department of Nephrology, Hospital Saint-Louis, Paris, France

* Michael Mengel, mmengel@ualberta.ca

Publication History

  1. Issue published online: 28 FEB 2012
  2. Article first published online: 2 FEB 2012
  3. Received 13 October 2011, revised 29 November 2011 and accepted for publication 30 November 2011

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Keywords:

  • Allograft rejection;
  • allograft transplantation;
  • antibody-mediated rejection;
  • Banff classification

The 11th Banff meeting was held in Paris, France, from June 5 to 10, 2011, with a focus on refining diagnostic criteria for antibody-mediated rejection (ABMR). The major outcome was the acknowledgment of C4d-negative ABMR in kidney transplants. Diagnostic criteria for ABMR have also been revisited in other types of transplants. It was recognized that ABMR is associated with heterogeneous phenotypes even within the same type of transplant. This highlights the necessity of further refining the respective diagnostic criteria, and is of particular significance for the design of randomized clinical trials. A reliable phenotyping will allow for definition of robust end-points. To address this unmet need and to allow for an evidence-based refinement of the Banff classification, Banff Working Groups presented multicenter data regarding the reproducibility of features relevant to the diagnosis of ABMR. However, the consensus was that more data are necessary and further Banff Working Group activities were initiated. A new Banff working group was created to define diagnostic criteria for ABMR in kidneys independent of C4d. Results are expected to be presented at the 12th Banff meeting to be held in 2013 in Brazil. No change to the Banff classification occurred in 2011.

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