Pancreas Transplantation From Donors After Circulatory Death From the United Kingdom
Article first published online: 27 JUL 2012
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 12, Issue 8, pages 2150–2156, August 2012
How to Cite
Muthusamy, A. S. R., Mumford, L., Hudson, A., Fuggle, S. V. and Friend, P. J. (2012), Pancreas Transplantation From Donors After Circulatory Death From the United Kingdom. American Journal of Transplantation, 12: 2150–2156. doi: 10.1111/j.1600-6143.2012.04075.x
- Issue published online: 27 JUL 2012
- Article first published online: 27 JUL 2012
- Received 11 October 2011, revised 28 February 2012 and accepted for publication 15 March 2012.
- donation after cardiac death;
- graft thrombosis;
- pancreas transplantation
This study reports the comparative short-term results of pancreas transplantation from donors after circulatory death (DCD) (Maastricht III & IV), and pancreases from brainstem deceased donors (DBD). Between January 2006 and December 2010, 1009 pancreas transplants were performed in the United Kingdom, with 134 grafts from DCD and 875 from DBD. DCD grafts had no premortem pharmacological interventions performed. One-year pancreas and patient survival was similar between DCD and DBD, with pancreas graft survival significantly better in the DCD cohort if performed as an SPK. Early graft loss due to thrombosis (8% vs. 4%) was mainly responsible for early graft loss in the DCD cohort. These results from donors with broader acceptance criteria in age, body mass index, premortem interventions, etc. suggest that DCD pancreas grafts may have a larger application potential than previously recognized.