Prospective Analysis of Human Cytomegalovirus DNAemia and Specific CD8+ T Cell Responses in Lung Transplant Recipients
Article first published online: 30 APR 2012
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 12, Issue 8, pages 2172–2180, August 2012
How to Cite
Weseslindtner, L., Kerschner, H., Steinacher, D., Nachbagauer, R., Kundi, M., Jaksch, P., Simon, B., Hatos-Agyi, L., Scheed, A., Klepetko, W. and Puchhammer-Stöckl, E. (2012), Prospective Analysis of Human Cytomegalovirus DNAemia and Specific CD8+ T Cell Responses in Lung Transplant Recipients. American Journal of Transplantation, 12: 2172–2180. doi: 10.1111/j.1600-6143.2012.04076.x
- Issue published online: 27 JUL 2012
- Article first published online: 30 APR 2012
- Received 02 December 2011, revised 15 February 2012 and accepted for publication 13 March 2012
Figure S1: HCMV-specific IFNG responses in representative HCMV-seropositive patients. (A, B) Representative HCMV-seropositive patients who displayed high-level HCMV DNAemia (plasma HCMV DNA loads exceeding 1000 copies/mL) and undetectable HCMV-specific IFNG responses during the entire follow-up (A) or detectable and stable responses (B). (C, D) Representative HCMV-seropositive patients with low-level HCMV DNAemia (plasma HCMV DNA loads equal to or lower than 1000 copies/mL) who showed HCMV-specific IFNG responses that were detected early during (C) or after antiviral prophylaxis (D) and remained stable thereafter.
Figure S2: HCMV-specific IFNG responses in representative HCMV-seronegative patients and in a seropositive patient with HCMV disease. (A, B, C) Representative HCMV-seronegative patients who developed primary HCMV-specific IFNG responses after high-level HCMV DNAemia (plasma HCMV DNA loads exceeding 1000 copies/mL) (A), low-level HCMV DNAemia (plasma HCMV DNA loads equal to or lower than 1000 copies/mL) (B) and no detectable HCMV DNAemia during the entire follow-up (C). (D) Representative patient with a D+/R+ constellation who showed fluctuations of HCMV-specific IFNG responses that decreased before high level HCMV DNAemia and HCMV disease.
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