Shared first authorship.
The Eurotransplant Donor Risk Index in Liver Transplantation: ET-DRI
Article first published online: 23 JUL 2012
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 12, Issue 10, pages 2789–2796, October 2012
How to Cite
Braat, A. E., Blok, J. J., Putter, H., Adam, R., Burroughs, A. K., Rahmel, A. O., Porte, R. J., Rogiers, X., Ringers, J. and for the European Liver and Intestine Transplant Association (ELITA) and Eurotransplant Liver Intestine Advisory Committee (ELIAC) (2012), The Eurotransplant Donor Risk Index in Liver Transplantation: ET-DRI. American Journal of Transplantation, 12: 2789–2796. doi: 10.1111/j.1600-6143.2012.04195.x
- Issue published online: 25 SEP 2012
- Article first published online: 23 JUL 2012
- Received 28 September 2011, revised 07 June 2012 and accepted for publication 08 June 2012
- Decision support techniques;
- liver transplantation outcome assessment;
- organ donation;
- risk factors
Recently we validated the donor risk index (DRI) as conducted by Feng et al. for the Eurotransplant region. Although this scoring system is a valid tool for scoring donor liver quality, for allocation purposes a scoring system tailored for the Eurotransplant region may be more appropriate. Objective of our study was to investigate various donor and transplant risk factors and design a risk model for the Eurotransplant region. This study is a database analysis of all 5939 liver transplantations from deceased donors into adult recipients from the 1st of January 2003 until the 31st of December 2007 in Eurotransplant. Data were analyzed with Kaplan–Meier and Cox regression models. From 5723 patients follow-up data were available with a mean of 2.5 years. After multivariate analysis the DRI (p < 0.0001), latest lab GGT (p = 0.005) and rescue allocation (p = 0.007) remained significant. These factors were used to create the Eurotransplant Donor Risk Index (ET-DRI). Concordance-index calculation shows this ET-DRI to have high predictive value for outcome after liver transplantation. Therefore, we advise the use of this ET-DRI for risk indication and possibly for allocation purposes within the Eurotrans-plant region.