Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile

Authors

Errata

This article is corrected by:

  1. Errata: Erratum Volume 13, Issue 8, 2231, Article first published online: 26 July 2013

Niels Olsen Saraiva Câmara, niels@icb.usp.br

Abstract

Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.

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