JT and YL contributed equally.
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Original Article
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Transmission of Angiosarcomas From a Common Multiorgan Donor to Four Transplant Recipients
Article first published online: 24 OCT 2012
DOI: 10.1111/j.1600-6143.2012.04301.x
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons
Additional Information
How to Cite
Thoning, J., Liu, Y., Bistrup, C., Thomassen, A., Borst, C., Marcussen, N. and Tepel, M. (2013), Transmission of Angiosarcomas From a Common Multiorgan Donor to Four Transplant Recipients. American Journal of Transplantation, 13: 167–173. doi: 10.1111/j.1600-6143.2012.04301.x
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JT and YL contributed equally.
Publication History
- Issue published online: 26 DEC 2012
- Article first published online: 24 OCT 2012
- Manuscript Revised: 30 AUG 2012
- Manuscript Accepted: 30 AUG 2012
- Manuscript Received: 26 JUN 2012
Funded by
- European Union. Grant Number: 62-1.2-10
- Danish Council for Independent Research. Grant Number: 10-084667
- Abstract
- Article
- References
- Cited By
Keywords:
- Angiosarcoma;
- donor tumor transmission;
- transplantation;
- urokinase-plasminogen-activator-receptor
We describe the donor tumor transmission of metastatic angiosarcomas to four transplant recipients through transplantation of deceased-donor organs, i.e. kidneys, lung and liver, from an apparently unaffected common female multiorgan donor. Fluorescent in situ hybridization of angiosarcoma cells confirmed that the tumor was of female donor's origin in male kidney recipients. Recent literature associated increased urokinase-plasminogen-activator-receptor (uPAR) and plasma soluble urokinase-plasminogen-activator-receptor (suPAR) levels with metastatic malignancies. Now we found that, compared to baseline levels, both deceased-donor kidney recipients showed increased uPAR transcripts in mononuclear cells as well as increased plasma suPAR levels after the diagnosis of metastatic angiosarcomas, i.e. 4 months after donor tumor transmission. These results show an association of uPAR/suPAR in donor tumor transmission of metastatic angiosarcomas in humans.