Research performed while Dr. Theodoropoulos was at Northwestern University; author is now at Ohio State University.
BK Virus Replication and Nephropathy After Alemtuzumab-Induced Kidney Transplantation
Article first published online: 8 NOV 2012
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 13, Issue 1, pages 197–206, January 2013
How to Cite
Theodoropoulos, N., Wang, E., Penugonda, S., Ladner, D. P., Stosor, V., Leventhal, J., Friedewald, J., Angarone, M. P. and Ison, M. G. (2013), BK Virus Replication and Nephropathy After Alemtuzumab-Induced Kidney Transplantation. American Journal of Transplantation, 13: 197–206. doi: 10.1111/j.1600-6143.2012.04314.x
The study was presented in part at the American Transplant Congress 2011, Philadelphia, Pennsylvania, USA.
- Issue published online: 26 DEC 2012
- Article first published online: 8 NOV 2012
- Manuscript Revised: 21 SEP 2012
- Manuscript Accepted: 21 SEP 2012
- Manuscript Received: 4 APR 2012
- Northwestern University Transplant Outcomes Research Collaborative (NUTORC)
- BK virus nephropathy;
- kidney transplantation;
- lymphocyte depletion
BK virus nephropathy (BKVN) is a recognized cause of graft failure in kidney transplant recipients. There are limited data on the epidemiology of BK virus (BKV) infection after alemtuzumab induction. By clinical protocol, the kidney transplant recipients at our center were screened with BKV plasma PCR monthly for the first 4 months posttransplant then every 2–3 months for 2 years. A single center retrospective cohort study of all kidney transplant recipients from January 2008 to August 2010 was conducted to determine incidence and outcomes of BKV infection. Descriptive statistics and Kaplan–Meier analysis was performed. Of 666 recipients, 250 (37.5%) developed viruria, 80 (12%) developed viremia and 31 (4.7%) developed BKVN at a median of 17, 21 and 30 weeks, respectively. Induction with alemtuzumab did not significantly affect incidence of BKVN. Increased recipient age, African American race, acute graft rejection and CMV infection were significantly associated with the development of BKVN in multivariate analysis. The incidence of BK viruria, viremia and nephropathy was not significantly different among kidney transplant recipients who received alemtuzumab induction compared to patients receiving less potent induction.