This special AJT supplement reports on the proceedings of the XII International Small Bowel Transplant Symposium, held in Washington, D.C., in 2011. This event facilitated the presentation of current science in the field, recent clinical advances, problems the scientific community encounters, and ongoing clinical challenges to the success of intestinal transplants. As immediate past-president of the Intestinal Transplant Association (ITA) and program chair, I was in a unique position to assimilate this information and influence its broader dissemination. While past symposia resulted in short non-peer-reviewed proceedings, this supplement represents the first forum through which AJT and the association worked together to provide you with some of the best work presented. Indeed, it reflects a shared commitment by the ITA and AJT to foster improvements in bowel transplantation. Multiple challenges remain for intestinal transplant recipients, and these present unique clinical and experimental opportunities to both advance the field and broaden our understanding of intestinal transplant biology. AJT recognizes the life-saving nature of this therapy, but also the importance of broader insights we may gain toward an understanding of transplant biology generally. Within these pages is a selection of some of the best of the meeting.