Release and diffusion through human tooth roots in vitro of corticosteroid and tetracycline trace molecules from Ledermix® paste
Version of Record online: 27 APR 2006
Volume 4, Issue 2, pages 55–62, April 1988
How to Cite
Abbott, P. V., Heithersay, G. S. and Hume, W. R. (1988), Release and diffusion through human tooth roots in vitro of corticosteroid and tetracycline trace molecules from Ledermix® paste. Dental Traumatology, 4: 55–62. doi: 10.1111/j.1600-9657.1988.tb00295.x
- Issue online: 27 APR 2006
- Version of Record online: 27 APR 2006
- Accepted for publication 19 October 1987.
Abstract The release of corticosteroid and antibiotic tracer molecules in Ledermix® paste from the pulp space to the external environment of human tooth roots was determined in vitro. For demeclocycline little of the tracer was released through the root apex; the great majority diffused through dentine. For triamcinolone about one-third of the tracer left the roots via the apical foramen; the remainder exited via the dentine. The rate of release of the tracers was highest during the first day, and declined exponentially with time thereafter. After 14 weeks, 98% of triamcinolone and 66% of demeclocycline had been released. In the teeth examined, diffusion rate was not related to the age or sex of the donor. Total release of the tracers was directly related to the area of contact between the paste and dentine. The data obtained are of immediate clinical relevance, and also add to our general understanding of drug dynamics in tooth roots.