Local injection of Benadryl® for the prevention of iatrogenic endodontic flare-ups
Version of Record online: 27 APR 2006
Volume 4, Issue 2, pages 90–91, April 1988
How to Cite
Nevins, A., Friedman, L., DeVita, R. and Schacter, W. (1988), Local injection of Benadryl® for the prevention of iatrogenic endodontic flare-ups. Dental Traumatology, 4: 90–91. doi: 10.1111/j.1600-9657.1988.tb00302.x
- Issue online: 27 APR 2006
- Version of Record online: 27 APR 2006
- Accepted for publication 16 October 1987.
- endodontic flare-up;
- symptomatic apical periodontitis;
Abstract Endodontic flare-ups often occur within 24 h of root canal debridement, during which time a small amount of antigen in the form of necrotic pulp tissue and bacteria within the root canal, may be inadvertently extruded through the apical foramen. Subsequently, preformed mediators such as histamine are released into the tissue, causing symptoms of pain and swelling. The IgE-mast cell mechanism conceivably plays an important role in this development. A rationale for using local injection of Benadryl® prior to canal debridement of infected teeth is given, along with an indication of a lack of adverse reactions and side effects following such treatment.