Department of Conservative Dentistry, St Bartholomew's and the Royal London School of Medicine and Dentistry, Turner Street, London El 2AD, UK
The frequency of fungal infection in biopsies of oral mucosal lesions
Article first published online: 28 JUN 2008
Volume 4, Issue 1, pages 26–31, March 1998
How to Cite
Barrett, A., Kingsmill, V. and Speight, P. (1998), The frequency of fungal infection in biopsies of oral mucosal lesions. Oral Diseases, 4: 26–31. doi: 10.1111/j.1601-0825.1998.tb00251.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received 13 August 1997; revised 16 October 1997, accepted 11 November 1997
- epithelial dysplasia
To determine the frequency of fungal infection in biopsies of oral mucosal lesions.
MATERIALS AND METHODS: Histopathology reports issued between 1991–1995 inclusive were reviewed. During this period, a single section of each mucosal biopsy had been stained using the periodic acid-Schiff (PAS) technique.
RESULTS: A total of 223 (4.7%) biopsies contained PAS-positive fungi: 191 individuals were affected, 124 (64.9%) of whom were male. There was a significant (P < 0.01) positive association of fungal infection with moderate and severe epithelial dysplasia, median rhomboid glossitis and squamous papillomas. Where a subsequent biopsy was available, 21.9% dysplasias which were infected with fungi worsened in histological severity, as compared with 7.6% of dysplasias which were not infected at any stage. There was a significant negative association of fungal infection with benign fibrous overgrowths (P < 0.01), benign hyperkeratoses, lichenoid reactions and pyogenic granulomas (P < 0.05). The difference in frequency of infection between the tongue and other sites was also significantly higher (P < 0.01).
CONCLUSIONS: There is a statistically significant association between histologically-determined fungal infection and epithelial dysplasia, and we recommend that a PAS stain be performed whenever oral epithelial dysplasia is diagnosed, especially in male patients. On histological confirmation of dysplasia, anti-fungal therapy should be considered in the management of these lesions.