Review of linear epidermal nevus with oral mucosal involvement – series of five new cases
Article first published online: 3 MAY 2007
© 2007 The Authors
Volume 14, Issue 2, pages 131–137, March 2008
How to Cite
Haberland-Carrodeguas, C., Allen, C., Lovas, J., Hicks, J., Flaitz, C., Carlos, R. and Stal, S. (2008), Review of linear epidermal nevus with oral mucosal involvement – series of five new cases. Oral Diseases, 14: 131–137. doi: 10.1111/j.1601-0825.2006.01355.x
- Issue published online: 3 MAY 2007
- Article first published online: 3 MAY 2007
- Received 25 September 2006; accepted 16 October 2006
- linear epidermal nevus;
- epidermal nevus syndromes;
- benign epithelial disorders;
- oral mucosa
Introduction: Linear epidermal nevi are sporadic hamartomatous alterations of the epidermis and superficial dermis that clinically appear as verrucous papules and plaques distributed in a linear pattern following Blaschko's lines. Their extent varies from unilateral involvement (nevus unius lateris) to extensive bilateral involvement (ichthyosis hystrix). Oral mucosal lesions have rarely been described.
Aims: We review the literature, focusing on the rare intraoral manifestations of linear epidermal nevus.
Case series: We present a series of five new cases with oral mucosal involvement. Four cases had associated cutaneous lesions and one case had oral lesions exclusively. Histopathologic evaluation of lesional tissue in four cases showed hyperkeratosis, acanthosis, epithelial hyperplasia, and papillomatosis. Dental abnormalities, consisting of enamel hypoplasia and congenitally missing teeth, were noted in one patient adjacent to the oral lesions.