Secretory cells in adenomatoid odontogenic tumour: tissue induction or metaplastic mineralisation?
Article first published online: 28 JUN 2008
© 2007 The Authors. Journal compilation © 2007 Blackwell Munksgaard
Volume 14, Issue 5, pages 445–449, July 2008
How to Cite
Jivan, V., Altini, M. and Meer, S. (2008), Secretory cells in adenomatoid odontogenic tumour: tissue induction or metaplastic mineralisation?. Oral Diseases, 14: 445–449. doi: 10.1111/j.1601-0825.2007.01399.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received 5 June 2006; revised 21 September 2006, 24 January 2007; accepted 10 April 2007
- odontogenic tumours;
- adenomatoid odontogenic tumour;
- metaplastic mineralisation
Objective: To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity.
Materials and methods: Haematoxylin and eosin stained sections of 51 cases of AOT were reviewed. Selected cases were stained with periodic acid-schiff (PAS) and Congo red.
Results: In five cases, secretory structures with a circular arrangement of tall columnar cells secreting enameloid-like matrix material were identified. Such structures have only very rarely been identified in AOT and their frequency, distribution and morphology have not been adequately documented.
Conclusions: We have documented the presence of tall secretory columnar cells, arranged in a circular configuration actively secreting enameloid-like material and believe that such an ordered arrangement of secretory cells is more likely a result of tissue induction rather than metaplasia. The origin of these secretory structures from the pseudo-ductular component is unlikely but cannot be ruled out.