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Hyptis pectinata essential oil: chemical composition and anti-Streptococcus mutans activity

Authors

  • PFC Nascimento,

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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  • WS Alviano,

    1. Departamento de Ortodontia, Faculdade de Odontologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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  • ALC Nascimento,

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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  • PO Santos,

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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  • MF Arrigoni-Blank,

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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  • RA De Jesus,

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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  • VG Azevedo,

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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  • DS Alviano,

    1. Laboratório de Estruturas de Superfície de Microrganismos, Departamento de Microbiologia Geral, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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  • AM Bolognese,

    1. Departamento de Ortodontia, Faculdade de Odontologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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  • RC Trindade

    1. Departamento de Fisiologia – CCBS, Laboratório de Farmacologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
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DS Alviano, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude-Bloco I, Ilha do Fundao, 21941-590 Rio de Janeiro, RJ, Brazil. Tel: +55 21 25626711, Fax: +55 21 25608344, E-mail: alviano@micro.ufrj.br

Abstract

Objectives:  The aim of the present study was to evaluate the anti-Streptococcus mutans activity of Hyptis pectinata essential oil, and present its promising potential against oral diseases.

Materials and methods:  The essential oil of H. pectinata was obtained by hydrodistillation from dried leaves and analyzed by GC / MS. The effectiveness of this essential oil regarding the antimicrobial activity against several S. mutans strains was investigated by the agar diffusion and microdilution methods, and chlorohexidine was used as a standard control.

Results:  The H. pectinata essential oil exhibited considerable inhibitory effect against either all the clinical isolates obtained from patients’ saliva or the ATCC strains tested, with minimum inhibitory and bactericidal concentrations of 200 μg ml−1. The study also compared the efficiency of the emulsifying agents Tween 20, Tween 80, dimethyl sulfoxide and propylene glycol in H. pectinata essential oil when tested against S. mutans. The data obtained confirmed the better inhibitory effect of the oil when using all tested diluents, although Tween 80 seemed to be more suitable for emulsification.

Conclusion:  According to our results, H. pectinata essential oil can be considered a promising alternative to chlorhexidine for the control of oral bacteria-related diseases and hygiene.

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