Mucosal graft-vs-host disease

  1. J Lew1,
  2. JA Smith2

Article first published online: 18 OCT 2007

DOI: 10.1111/j.1601-0825.2007.01412.x

Issue

Oral Diseases

Oral Diseases

Volume 13, Issue 6, pages 519–529, November 2007

Additional Information

How to Cite

Lew, J. and Smith, J. (2007), Mucosal graft-vs-host disease. Oral Diseases, 13: 519–529. doi: 10.1111/j.1601-0825.2007.01412.x

Author Information

  1. 1

    Laboratory of Immunology

  2. 2

    Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, MD, USA

*Janine A. Smith MD, Division of Epidemiology and Clinical Research, National Eye Institute, 10 Center Drive, MSC 1863, Bldg 10/ Room 10S 227, Bethesda, MD 20892-1863, USA. Tel: 301-435-4568, Fax: 301-480-6523, E-mail: smithj@nei.nih.gov

Publication History

  1. Issue published online: 18 OCT 2007
  2. Article first published online: 18 OCT 2007
  3. Received 15 June 2007; accepted 18 June 2007

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Keywords:

  • mucosa;
  • inflammatory disease;
  • stem cell transplantation

Graft-vs-host disease (GVHD) is a serious complication of hematopoietic stem cell transplantation (HSCT). Indications for HSCT have greatly expanded, and more patients are undergoing HSCT today than ever before. In addition, the options for immunosuppressive therapy for both prevention and treatment of GVHD have also expanded. These changes have in turn altered the landscape of this disease. We have reviewed the current literature on this subject and presented an update on this disease with a particular emphasis on mucosal manifestations.

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