These authors contributed equally to this work.
Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
Version of Record online: 6 MAR 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Volume 14, Issue 7, pages 626–632, October 2008
How to Cite
Kim, J.-Y., Kim, S.-T., Cho, S.-W., Jung, H.-S., Park, K.-T. and Son, H.-K. (2008), Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible. Oral Diseases, 14: 626–632. doi: 10.1111/j.1601-0825.2007.01435.x
- Issue online: 30 SEP 2008
- Version of Record online: 6 MAR 2008
- Received 12 July 2007; revised 7 October 2007; accepted 13 November 2007
- botulinum toxin type A;
- masseter muscle;
- rat mandible;
- condylar cartilage
Objectives: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible.
Materials and methods: Four-week-old male (no. 80) Sprague–Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks.
Results: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes.
Conclusions: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.