Oral graft-versus-host disease
Article first published online: 28 JUN 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Volume 14, Issue 5, pages 396–412, July 2008
How to Cite
Imanguli, M., Alevizos, I., Brown, R., Pavletic, S. and Atkinson, J. (2008), Oral graft-versus-host disease. Oral Diseases, 14: 396–412. doi: 10.1111/j.1601-0825.2008.01448.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received 20 February 2008; revised 27 March 2008; accepted 1 April 2008
- graft-versus host disease;
- salivary gland disease;
- hematopoietic stem cell transplant
Objective: Graft-versus-host disease (GVHD) is a leading cause of morbidity and mortality in patients receiving hematopoietic cell transplant. It is estimated that 40–70% of engrafted patients surviving the initial transplant eventually develop chronic GVHD (cGVHD), which can persist for months to years and require long-term management from multiple disciplines. This review describes the oral component of this transplant complication.
Design: The search related to GVHD patho-biology, salivary gland disease after hematopoietic cell transplant and treatments for oral GVHD encompassed literature from 1966 through 2008. Searches were limited to the MEDLINE/PubMed database and English language literature in peer-reviewed journals.
Results: Our understanding of the patho-biology of oral cGVHD is based on studies of other affected tissues. It is difficult to determine the prevalence and incidence of salivary gland disease after transplant because there is no universally accepted case definition. In general, clinical trials for treatment of oral cGVHD have been too small to make strong recommendations for use in clinical practice.
Conclusions: Larger well-designed clinical studies are needed to understand the patho-biology of oral cGVHD and determine best treatments for this disease.