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Genetic contributions to pain: a review of findings in humans
Article first published online: 7 OCT 2008
DOI: 10.1111/j.1601-0825.2008.01458.x
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Additional Information
How to Cite
Fillingim, R., Wallace, M., Herbstman, D., Ribeiro-Dasilva, M. and Staud, R. (2008), Genetic contributions to pain: a review of findings in humans. Oral Diseases, 14: 673–682. doi: 10.1111/j.1601-0825.2008.01458.x
Publication History
- Issue published online: 15 OCT 2008
- Article first published online: 7 OCT 2008
- Received 25 April 2008; accepted 30 April 2008
- Abstract
- Article
- References
- Cited By
Keywords:
- pain;
- genetics;
- pain sensitivity;
- chronic pain;
- orofacial pain
Pain represents the major motivating factor for which individuals seek healthcare, and pain responses are characterized by substantial inter-individual differences. Increasing evidence suggests that genetic factors contribute significantly to individual differences in responses to both clinical and experimental pain. The purpose of this review article was to summarize the current literature regarding genetic contributions to pain, highlighting findings relevant to oral pain where available. A brief discussion of methodologic considerations is followed by a review of findings regarding genetic influences on clinical pain. Next, the literature examining genetic contributions to experimental pain responses is presented, emphasizing genetic associations that have been replicated in multiple cohorts. It is hoped that an enhanced understanding of genetic contributions to pain responses will ultimately improve diagnosis and treatment of clinical pain conditions.