Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population

  1. LM Xiao1,†,
  2. YX Yan1,†,
  3. CJ Xie1,
  4. WH Fan2,
  5. DY Xuan2,
  6. CX Wang2,
  7. L Chen2,
  8. SY Sun2,
  9. BY Xie2,
  10. JC Zhang2

Article first published online: 22 JUN 2009

DOI: 10.1111/j.1601-0825.2009.01584.x

Issue

Oral Diseases

Oral Diseases

Volume 15, Issue 8, pages 547–553, November 2009

Additional Information

How to Cite

Xiao, L., Yan, Y., Xie, C., Fan, W., Xuan, D., Wang, C., Chen, L., Sun, S., Xie, B. and Zhang, J. (2009), Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population. Oral Diseases, 15: 547–553. doi: 10.1111/j.1601-0825.2009.01584.x

Author Information

  1. 1

    Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China

  2. 2

    Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China

  1. †

    These authors contributed equally to this study.

*Dr JC Zhang, Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, S366 Jiangnan Boulevard, Guangzhou 510280, China. Tel: 86 208441 3940, Fax: 86 208443 3177, E-mail: jincaizhang-1@hotmail.com

Publication History

  1. Issue published online: 7 OCT 2009
  2. Article first published online: 22 JUN 2009
  3. Received 23 February 2009; revised 4 May 2009; accepted 7 May 2009

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Keywords:

  • chronic periodontitis;
  • type 2 diabetes mellitus;
  • polymorphism;
  • interleukin-6;
  • Chinese

Objectives:  Diabetics significantly increase risk for periodontitis. Interleukin-6 (IL-6) gene polymorphism may play certain roles in the progression of periodontitis with diabetes. The purpose of this study was to assess the association among IL-6 gene polymorphisms, type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP) in a Chinese population.

Material and methods:  DNA was obtained from 159 patients with CP, 88 patients with T2DM, 110 patients with CP&T2DM and 135 control subjects. The -174/-572/-597 polymorphisms of IL-6 gene were investigated by restriction fragment length polymorphism of polymerase chain reaction products. The results were further confirmed by sequencing. Significance was set at P < 0.008 after Bonferroni correction.

Results:  Among four groups, CP&T2DM group showed the lowest IL-6-572 CC genotype and C-allele frequencies (54.5% and 74.1%). In this regard, there were significant differences between CP&T2DM group and the control group [P = 0.006, odds ratio (OR) = 0.475, 95% CI: 0.279–0.808 and P = 0.002, OR = 0.502, 95% CI: 0.319–0.788 respectively]. Logistic regression with adjustment for age, gender, body mass index, smoking and stress showed no significant difference in terms of IL-6-572 genotypes (P = 0.058, OR= 0.523, 95% CI: 0.268–1.022).

Conclusions:  The IL-6-572 genotype and allele distributions are unique to subjects with CP&T2DM in a Chinese population.

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