Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection
Article first published online: 29 JUL 2009
© 2009 John Wiley & Sons A/S
Volume 16, Issue 2, pages 156–159, March 2010
How to Cite
Andric, M., Dozic, B., Popovic, B., Stefanovic, D., Basta-Jovanovic, G., Djogo, N., Andjus, P. and Milasin, J. (2010), Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection. Oral Diseases, 16: 156–159. doi: 10.1111/j.1601-0825.2009.01612.x
- Issue published online: 19 FEB 2010
- Article first published online: 29 JUL 2009
- Received 21 April 2009; revised 09 June 2009; accepted 29 June 2009
- survivin expression;
- odontogenic keratocyst;
- keratocystic odontogenic tumor;
- periapical cyst
Oral Diseases (2010) 16, 156–159
Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts – periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts.
Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin.
Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts.
Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.