Oral manifestations of human T-cell lymphotropic virus infection in adult patients from Brazil
Article first published online: 19 FEB 2010
© 2010 John Wiley & Sons A/S
Volume 16, Issue 2, pages 167–171, March 2010
How to Cite
Martins, F., Casseb, J., Penalva-de-Oliveira, A., De Paiva, M., Watanuki, F. and Ortega, K. (2010), Oral manifestations of human T-cell lymphotropic virus infection in adult patients from Brazil. Oral Diseases, 16: 167–171. doi: 10.1111/j.1601-0825.2009.01638.x
- Issue published online: 19 FEB 2010
- Article first published online: 19 FEB 2010
- Received 11 May 2009; revised 17 June 2009; accepted 16 July 2009
- human T-cell lymphotropic virus;
- oral manifestations;
- HTLV-associated myelopathy/tropical spastic paraparesis
Oral Diseases (2010) 16, 167–171
Objective: Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus discovered and its pathogenesis is related to T cells infection. This study aimed to verify the presence of oral manifestations in a Brazilian population of patients who was seropositive for HTLV, and identify risk factors for oral manifestations.
Subjects and methods: An assessment was made of 139 patients at the Emilio Ribas Institute of Infectious Diseases.
Results: A total of 112 (80.5%) patients were HTLV-1, 26 (18.7%) were HTLV-2+. About 35.2% of patients had myelopathy/tropical spastic paraparesis (HAM/TSP), with 48 of them being HTLV-1+ and one patient was seropositive for HTLV-1 and -2. The most common oral manifestations were: xerostomia (26.8%), candidiasis (20.8%), fissured tongue (17.9%), and loss of tongue papillae (10.0%). A multivariate logistic regression analysis showed that HAM/TSP is an independent risk factor for xerostomia (P = 0.02). The patients who were HAM/TSP+ were three times more likely to develop xerostomia when compared with patients without HAM/TSP (odds ratio = 2.69, 95% confidence interval = 1.17–6.17).
Conclusion: Despite the fact that the findings of this study suggest a relationship between xerostomia and HAM/TSP, more studies should be developed to show what the association would be between xerostomia presented by HTLV patients and pathogenesis of the virus.