Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis
Article first published online: 19 APR 2010
© 2010 John Wiley & Sons A/S
Volume 16, Issue 7, pages 601–612, October 2010
How to Cite
Lodi, G., Pellicano, R. and Carrozzo, M. (2010), Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Oral Diseases, 16: 601–612. doi: 10.1111/j.1601-0825.2010.01670.x
- Issue published online: 15 SEP 2010
- Article first published online: 19 APR 2010
- Received 25 September 2009; revised 4 November 2009; accepted 10 November 2009
- lichen planus;
- oral lichen planus;
- hepatitis C virus;
Oral Diseases (2010) 16, 601–612
Objective: Hepatitis C virus (HCV) is one of the major causes of chronic liver disease worldwide but its morbidity is also due to a variety of extra-hepatic manifestations including mixed cryoglubulinemia, non–Hodgkin lymphoma, diabetes, porphyria cutanea tarda and lichen planus. The aims of this study were to conduct a systematic review and a meta-analysis on the prevalence of HCV in lichen planus patients and on the prevalence of lichen planus in chronic HCV infection.
Materials and Method: Bibliographic searches were conducted in several electronic databases. Pooled data were analysed by calculating odds ratios, using a random effects model.
Results and Conclusions: Thirty-three studies comparing the seroprevalence of HCV in lichen planus patients and six reporting the prevalence of lichen planus in patients with HCV infection were included in the meta-analysis. The summary estimate showed that LP patients have significantly higher risk (odds ratio 4.85; 95% confidence interval 3.58–6.56) than controls of being HCV seropositive. A similar odds ratio of having lichen planus was found among HCV patients (4.47; 95% confidence interval 1.84–10.86). Sub-analyses indicated that variability of HCV/lichen planus association seemed only partially depending on geographic effect.