Salivary osteocalcin levels are decreased in smoker chronic periodontitis patients
Article first published online: 26 AUG 2010
© 2010 John Wiley & Sons A/S
Volume 17, Issue 2, pages 200–205, March 2011
How to Cite
Özçaka, Ö., Nalbantsoy, A. and Buduneli, N. (2011), Salivary osteocalcin levels are decreased in smoker chronic periodontitis patients. Oral Diseases, 17: 200–205. doi: 10.1111/j.1601-0825.2010.01721.x
- Issue published online: 14 FEB 2011
- Article first published online: 26 AUG 2010
- Received 25 December 2009; revised 9 March 2010; accepted 23 March 2010
Oral Diseases (2011) 17, 200–205
Objectives: This study was planned to investigate whether smoker chronic periodontitis patients exhibit different salivary concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the non-smoker counterparts.
Methods: Whole saliva samples, full-mouth clinical periodontal recordings were obtained from 33 otherwise healthy chronic periodontitis patients and 36 systemically, periodontally healthy control subjects. Chronic periodontitis patients and healthy control subjects were divided into smoker and non-smoker groups according to their self reports. Salivary ICTP, OC levels were determined by Enzyme-linked Immunoassays.
Results: Healthy control groups exhibited significantly lower values in all clinical periodontal measurements (P < 0.001). Smoker periodontitis patients revealed similar clinical periodontal index values with non-smoker counterparts (P > 0.05). Chronic periodontitis patients exhibited significantly higher salivary OC levels than healthy controls (P < 0.05). Smoker periodontitis patients revealed lower salivary OC levels than non-smoker counterparts (P < 0.001). Log ICTP levels in non-smoker chronic periodontitis patients were higher than non-smoker controls (P < 0.05). Smoker healthy control group revealed higher log ICTP levels than non-smoker counterparts (P < 0.001).
Conclusions: Within the limits of this study, it may be suggested that suppression of salivary osteocalcin level by smoking may at least partly explain the deleterious effects of smoking on periodontal status.