Parathyroid hormone and its effects on dental tissues

Authors


Athanasios Zavras, DMD, MS, DrMSc, Division of Oral Epidemiology and Biostatistics, Columbia University College of Dental Medicine 601 W 168th Str., Suite 34, New York, NY 10032, USA. Tel: (212)342-0425, Fax: (212) 342-8558, E-mail: az2256@mail.cumc.columbia.edu

Abstract

Oral Diseases (2011) 18, 48–54

In the current era, various pharmacological agents exist for osteoporosis management, and synthetic parathyroid hormone (PTH) (Teriparatide, Forteo) is one of the treatment options. Depending on the timing of administration, PTH has a unique ability to cause both bone apposition and bone resorption. This review focuses on the effects of PTH on the bone, specifically the jaw bones mandible and maxilla. The article briefly describes the fundamental mechanism of PTH action at the molecular level, as well as in experimental animals and in humans. It differentiates intermittent administration of PTH, especially at doses tolerated by humans that increase bone strength and prevent bone fractures, from continuous use that may lead to bone loss. In particular, it shows how intermittent administration of PTH can play a significant role in periodontal repair and implant success via stimulation of bone mineral content especially in the pre-alveolar region.

Ancillary