These authors contributed equally to this work.
Association of HPV infections with second primary tumors in early-staged oral cavity cancer
Article first published online: 2 JUL 2012
© 2012 John Wiley & Sons A/S
Volume 18, Issue 8, pages 809–815, November 2012
How to Cite
Huang, S.-F., Li, H.-F., Liao, C.-T., Wang, H.-M., Chen, I.-H., Chang, J.-C., Chen, Y.-J. and Cheng, A.-J. (2012), Association of HPV infections with second primary tumors in early-staged oral cavity cancer. Oral Diseases, 18: 809–815. doi: 10.1111/j.1601-0825.2012.01950.x
- Issue published online: 26 SEP 2012
- Article first published online: 2 JUL 2012
- Accepted manuscript online: 25 MAY 2012 11:16AM EST
- Received 10 November 2011; revised 4 May 2012; accepted 11 May 2012
- human papilloma virus;
- oral cavity cancer;
- secondary malignancy;
- risk exposure;
- clinical association
Oral Diseases (2012) 18, 809–815
Objective: The infection of human papilloma virus (HPV) has been reported in head and neck cancer; however, the clinical significance of HPV infection on the pathogenesis of oral cavity squamous cell carcinoma (OSCC) is still uncertain.
Materials and Methods: The study recruited 103 patients with pathological early-stage OSCC between March 1997 and December 2003 from Chang Gung Memorial Hospital, Taiwan. Tumor specimens were HPV-genotyped by the EasychipVR HPV Blot method. Clinical association study was performed by using chi-square, Kaplan–Meier, and logrank tests.
Results: Thirty-one patients (30.1%) were positive for HPV infection. The most frequent HPV types were types 16 (16 patients, 51.6%) and 18 (seven patients, 22.6%). HPV infection was not associated with tumor aggressiveness (pathological tumor stage or differentiation status), risk exposure (alcohol, cigarette, or areca quid chewing habit), or the treatment outcome (disease-free survival or overall survival). However, infection with HPV-18 was associated with the occurrence of a second primary cancers (P = 0.033), indicating the infection of HPV in OSCC enhances the susceptibility of developing secondary malignancy.
Conclusions: There are 30% of the patients with OSCC infected with HPV, with most high-risk types. HPV-18 infection may enhance the susceptibility of second primary tumors. Large scale of validation study will be needed to confirm this result.