• odontogenic cysts;
  • jaws, oral;
  • dendritic cells;
  • immunohistochemistry

Oral Diseases (2012) 19, 85–91

Objective:  To analyze the expression and distribution patterns of mature dendritic cells (mDCs) and immature DCs (imDCs) in radicular cysts (RCs), dentigerous cysts (DtCs), and keratocystic odontogenic tumors (KCOTs).

Materials and methods:  Forty-nine odontogenic cystic lesions (OCLs) (RCs, n = 20; DtCs, n = 15; KCOTs, n = 14) were assessed using the following markers: S100, CD1a and CD207 for imDCs; and CD83 for mDCs.

Results:  Almost all cases were S100, CD1a, and CD207 positive, whereas 63% were CD83 positive. RCs presented greater number of immunostained cells, followed by DtCs, and KCOTs. The number of S100+ cells was greater than both CD1a+ and CD207+ cells (< 0.001), which showed approximately similar amounts, followed by lower number of CD83+ cells (< 0.001) in each OCL type. Different from S100+ cells, both CD1a+ and CD207+ cells on the epithelium (< 0.05) and CD83+ cells on the capsule (< 0.05) were preferentially observed. In RCs, significant correlation was found between the thickness epithelium with S100+ and CD1a+ cells, and between the degree of inflammation with CD83+ cells.

Conclusions:  Dendritic cell populations in OCLs can be phenotypically heterogeneous, and it could represent distinct lineages and/or functional stages. It is suggested that besides DC-mediated immune cell interactions, DC-mediated tissue differentiation and maintenance in OCLs should also be considered.