• Asberg, M., Traskman, L. & Thoren, P. (1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33, 11931197.
  • American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. American Psychiatric Association, Washington DC.
  • Chen, Y.W. & Dilsaver, S.C. (1996) Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders. Biol Psychiatry 39, 896899.
  • Dalton, E.J., Cate-Carter, T.D., Mundo, E., Parikh, S.V. & Kennedy, J.L. (2003) Suicide risk in bipolar patients: the role of co-morbid substance use disorders. Bipolar Disord 5, 5861.
  • Fitzpatrick, P.F. (1999) Tetrahydropterin-dependent amino acid hydroxylases. Annu Rev Biochem 68, 355381.
  • Goodwin, F.K. & Jaminson, K.R. (1990) Manic Depressive – A Definitive Overview of Bipolar Disorder. Oxford University Press, New York.
  • Kennedy, M.A., Miller, A.L., Rogers, G., Luty, S., Mulder, R. & Joyce, P. (2003) Polymorphic variants and association analysis of TPH2, brain tryptophan hydroxylase. Neuropsychiatric Genet 122B, 69.
  • Lalovic, A. & Turecki, G. (2002) Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am J Med Genet 114B, 533540.
  • Mann, J.J. (1995) Violence and aggression. In: F.E. Bloom & D.J. Kupfer (eds), Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, pp. 1919–1928.
  • Meltzer, H.Y. (2005) Suicide in schizophrenia, clozapine and adoption of evidence-based medicine. J Clin Psychiatry 66, 530533.
  • Nielsen, D.A., Virkkunen, M., Lappalainen, J., Eggert, M., Brown, G.L., Long, J.C., Goldman, D. & Linnoila, M. (1998) A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55, 593602.
  • Nordstrom, P., Samuelsson, M., Asberg, M., Traskman-Bendz, L., Aberg-Wistedt, A., Nordin, C. & Bertilsson, L. (1994) CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide Life Threat Behav 24, 19.
  • Roy, A. (1993) Genetic and biologic risk factors for suicide in depressive disorders. Psychiatr Q 64, 345358.
  • Rujescu, D., Giegling, I., Sato, T., Hartmann, A.M. & Moller, H.J. (2003) Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. Biol Psychiatry 54, 465473.
  • Seltman, H., Roeder, K. & Devlin, B. (2003) Evolutionary-based association analysis using haplotype data. Genet Epidemiol 25, 4858.
  • Stack, S. (2000) Suicide: a 15-year review of the sociological literature. Part I: cultural and economic factors. Suicide Life Threat Behav 30, 145162.
  • Walther, D.J. & Bader, M. (2003) A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66, 16731680.
  • Walther, D.J., Peter, J.U., Bashammakh, S., Hortnagl, H., Voits, M., Fink, H. & Bader, M. (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299, 76.
  • Weiss, K.M. & Terwilliger, J.D. (2000) How many diseases does it take to map a gene with SNPs? Nat Genet 26, 151157.
  • Zill, P., Buttner, A., Eisenmenger, W., Bondy, B. & Ackenheil, M. (2004a) Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains. Eur Neuropsychopharmacol 14, 282284.
  • Zill, P., Baghai, T.C., Zwanzger, P., Schule, C., Eser, D., Rupprecht, R., Moller, H.J., Bondy, B. & Ackenheil, M. (2004b) SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 9, 10301036.
  • Zill, P., Buttner, A., Eisenmenger, W., Moller, H.J., Bondy, B. & Ackenheil, M. (2004c) Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 56, 581586.