SEARCH

SEARCH BY CITATION

References

  • Ahearn, E.P., Speer, M.C., Chen, Y.T., Steffens, D.C., Cassidy, F., Van Meter, S., Provenzale, J.M., Weisler, R.H. & Krishnan, K.R. (2002) Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. Am J Med Genet 114, 652658.
  • Akil, H. (2005) Stressed and depressed. Nat Med 11, 116118.
  • Belmonte, M.K., Cook, E.H. Jr. Anderson, G.M., Rubenstein, J.L., Greenough, W.T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L.M., Powell, S.B., Levitt, P.R., Perry, E.K., Jiang, Y.H., DeLorey, T.M. & Tierney, E. (2004) Autism as a disorder of neural information processing: directions for research and targets for therapy. Mol Psychiatry 9, 646663.
  • Berman, R.M., Narasimhan, M., Miller, H.L., Anand, A., Cappiello, A., Oren, D.A., Heninger, G.R. & Charney, D.S. (1999) Transient depressive relapse induced by catecholamine depletion: potential phenotypic vulnerability marker? Arch Gen Psychiatry 56, 395403.
  • Bogani, D., Willoughby, C., Davies, J. et al. (2005) Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen. Proc Natl Acad Sci USA 102, 1247712482.
  • Braff, D.L. & Freedman, R. (2002) Endophenotypes in studies of the genetics of schizophrenia. In Davis, K.L., Charney, D.S., Coyle, J.T. & Nemeroff, C. (eds), Neuropsychopharmacology: the Fifth Generation of Progress. Lippincott Williams & Wilkens, Philadelphia, pp. 703716.
  • Brandon, N.J., Handford, E.J., Schurov, I., Rain, J.C., Pelling, M., Duran-Jimeniz, B., Camargo, L.M., Oliver, K.R., Beher, D., Shearman, M.S. & Whiting, P.J. (2004) Disrupted in schizophrenia 1 and nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci 25, 4255.
  • Castellanos, F.X. & Tannock, R. (2002) Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 3, 617628.
  • Chamberlain, S.R., Blackwell, A.D., Fineberg, N.A., Robbins, T.W. & Sahakian, B.J. (2005) The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 29, 399419.
  • Charney, D.S., Barlow, D.H., Botteron, K.N., Cohen, J.D., Goldman, D., Gur, R.C., Lin, K.M., Lopez, J.F., Meador-Woodruff, J.H., Moldin, S.O., Nestler, E.J., Watson, S.J. & Zalcman, S.J. (2002) Neuroscience research agenda to guide development of a pathophysiologically based classification system. In Kupfer, D.J., First, M.B. & Regier, D.A. (eds), A Research Agenda For DSMV, pp. 31−83. American Psychiatric Association, Washington, DC.
  • Crawley, J.N. (2000) What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice. Wiley-Liss, New York.
  • Cronbach, L.J. & Meehl, P.E. (1955) Construct validity in psychological tests. Psychol Bull 52, 281302.
  • Crowley, J.J. & Lucki, I. (2005) Opportunities to discover genes regulating depression and antidepressant response from rodent behavioral genetics. Curr Pharm Des 11, 157169.
  • Crusio, W.E. (2001) Genetic dissection of mouse exploratory behaviour. Behav Brain Res 125, 127132.
  • Crusio, W.E. (2004) Flanking gene and genetic background problems in genetically manipulated mice. Biol Psychiatry 56, 381385.
  • Cryan, J.F. & Holmes, A. (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 4, 775790.
  • Dick, D.M., Jones, K., Saccone, N., Hinrichs, A., Wang, J.C., Goate, A., Bierut, L., Almasy, L., Schuckit, M., Hesselbrock, V., Tischfield, J., Fouround, T., Edenberg, H., Porjesz, B. & Begleiter, H. Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. Behav Genet (in press).
  • Doyle, A.E., Willcutt, E.G., Seidman, L.J., Biederman, J., Chouinard, V.A., Silva, J. & Faraone, S.V. (2005) Attention-deficit/hyperactivity disorder endophenotypes. Biol Psychiatry 57, 13241335.
  • Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B. & Weinberger, D.R. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257269.
  • Einat, H. Modeling facets of mania – new directions related to the notion of endophenotypes. J Psychopharmacol (in press).
  • Einat, H., Manji, H.K. & Belmaker, R.H. (2003) New approaches to modeling bipolar disorder. Psychopharmacol Bull 37, 4763.
  • Flint, J., Valdar, W., Shifman, S. & Mott, R. (2005) Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 6, 271286.
  • Gerlai, R. (2001) Gene targeting: technical confounds and potential solutions in behavioral brain research. Behav Brain Res 125, 1321.
  • Gershon, E.S. & Goldin, L.R. (1986) Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies. Acta Psychiatr Scand 74, 113118.
  • Geyer, M.A., McIlwain, K.L. & Paylor, R. (2002) Mouse genetic models for prepulse inhibition: an early review. Mol Psychiatry 7, 10391053.
  • Glahn, D.C., Bearden, C.E., Niendam, T.A. & Escamilla, M.A. (2004) The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord 6, 171182.
  • Gottesman, I.I. (1997) Twins: en route to QTLs for cognition. Science 276, 15221523.
  • Gottesman, I.I. & Erlenmeyer-Kimling, L. (2001) Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia. Schizophr Res 51, 93102.
  • Gottesman, I.I. & Gould, T.D. (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160, 636645.
  • Gottesman, I.I. & Shields, J. (1967) A polygenic theory of schizophrenia. Proc Natl Acad Sci USA 58, 199205.
  • Gottesman, I.I. & Shields, J. (1972) Schizophrenia and Genetics; a Twin Study Vantage Point. Academic Press Inc, New York.
  • Gottesman, I.I. & Shields, J. (1973) Genetic theorizing and schizophrenia. Br J Psychiatry 122, 1530.
  • Gould, T.D. & Manji, H.K. (2004) The molecular medicine revolution and psychiatry: bridging the gap between basic neuroscience research and clinical psychiatry. J Clin Psychiatry 65, 598604.
  • Gould, T.D., Bastain, T.M., Israel, M.E., Hommer, D.W., Castellanos, F.X. (2001) Altered performance on an ocular fixation task in attention-deficit/hyperactivity disorder. Biol Psychiatry 50, 633635.
  • Gould, T.D., Gray, N.A. & Manji, H.K. (2003) The cellular neurobiology of severe mood and anxiety disorders: implications for the development of novel therapeutics. In Charney, D.S. (ed.), Molecular Neurobiology for the Clinician. American Psychiatric Press Inc., Washington, pp. 123227.
  • Green, M.F., Nuechterlein, K.H., Gold, J.M., Barch, D.M., Cohen, J., Essock, S., Fenton, W.S., Frese, F., Goldberg, T.E., Heaton, R.K., Keefe, R.S., Kern, R.S., Kraemer, H., Stover, E., Weinberger, D.R., Zalcman, S. & Marder, S.R. (2004) Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry 56, 301307.
  • Hariri, A.R. & Weinberger, D.R. (2003) Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes Brain Behav 2, 341349.
  • Hariri, A.R., Goldberg, T.E., Mattay, V.S., Kolachana, B.S., Callicott, J.H., Egan, M.F. & Weinberger, D.R. (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23, 66906694.
  • Harrison, P.J. & Weinberger, D.R. (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10, 4068; image 45.
  • Hasler, G., Drevets, W.C., Manji, H.K. & Charney, D.S. (2004) Discovering endophenotypes for major depression. Neuropsychopharmacology 29, 17651781.
  • Hasler, G., Drevets, W.C., Gould, T.D., Gottesman, I.I. & Manji, H.K. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry (in press).
  • Heinrichs, R.W. (2005) The primacy of cognition in schizophrenia. Am Psychol 60, 229242.
  • Henderson, N.D., Turri, M.G., DeFries, J.C. & Flint, J. (2004) QTL analysis of multiple behavioral measures of anxiety in mice. Behav Genet 34, 267293.
  • Joober, R., Zarate, J.M., Rouleau, G.A., Skamene, E. & Boksa, P. (2002) Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle. Neuropsychopharmacology 27, 765781.
  • Kirov, G., O'Donovan, M.C. & Owen, M.J. (2005) Finding schizophrenia genes. J Clin Invest 115, 14401448.
  • Krishnan, K.R. (2005) Psychiatric disease in the genomic era: rational approach. Mol Psychiatry 10, 978984.
  • Kurz, A., Riemenschneider, M., Drzezga, A. & Lautenschlager, N. (2002) The role of biological markers in the early and differential diagnosis of Alzheimer's disease. J Neural Transm Suppl 62, 127133.
  • Leboyer, M., Bellivier, F., Nosten-Bertrand, M., Jouvent, R., Pauls, D. & Mallet, J. (1998) Psychiatric genetics: search for phenotypes. Trends Neurosci 21, 102105.
  • Lenox, R.H., Gould, T.D. & Manji, H.K. (2002) Endophenotypes in bipolar disorder. Am J Med Genet 114, 391406.
  • Lenzenweger, M.F. (1999) Schizophrenia: refining the phenotype, resolving endophenotypes. Behav Res Ther 37, 281295.
  • Lu, B. (2003) BDNF and activity-dependent synaptic modulation. Learn Mem 10, 8698.
  • Maher, M.A. & Gottesman, I.I., Deconstructing, reconstructing, and preserving Paul E. Meehl's legacy of construct validity. Psychol Assess (in press).
  • Manji, H.K., Gottesman, I.I. & Gould, T.D. (2003) Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Sci STKE 2003: pe49.
  • McDonald, C., Bullmore, E.T., Sham, P.C., Chitnis, X., Wickham, H., Bramon, E. & Murray, R.M. (2004) Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry 61, 974984.
  • Miguel, E.C., Leckman, J.F., Rauch, S., Do Rosario-Campos, M.C., Hounie, A.G., Mercadante, M.T., Chacon, P. & Pauls, D.L. (2005) Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry 10, 258275.
  • Nestler, E.J., Gould, E., Manji, H.K., Buncan, M., Duman, R.S., Greshenfeld, H.K., Hen, R., Koester, S., Lederhendler, I., Meaney, M., Robbins, T., Winsky, L. & Zalcman, S. (2002) Preclinical models: status of basic research in depression. Biol Psychiatry 52, 503528.
  • Neugroschl, J. & Davis, K.L. (2002) Biological markers in Alzheimer disease. Am J Geriatr Psychiatry 10, 660677.
  • Niculescu, A.B. III & Akiskal, H.S. (2001) Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations. Mol Psychiatry 6, 363366.
  • Petryshen, T.L., Kirby, A., Hammer, R.P., Jr Purcell, S., Singer, J.B., Hill, A.E., Nadeau, J.H., Daly, M.J. & Sklar, P. (2005) Two QTLs for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains. Genetics. doi:10.1534/genetics.105.045658
  • Pezawas, L., Verchinski, B.A., Mattay, V.S., Callicott, J.H., Kolachana, B.S., Straub, R.E., Egan, M.F., Meyer-Lindenberg, A. & Weinberger, D.R. (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24, 1009910102.
  • Phillips, T.J., Belknap, J.K., Hitzemann, R.J., Buck, K.J., Cunningham, C.L. & Crabbe, J.C. (2002) Harnessing the mouse to unravel the genetics of human disease. Genes Brain Behav 1, 1426.
  • Porjesz, B., Rangaswamy, M., Kamarajan, C., Jones, K.A., Padmanabhapillai, A. & Begleiter, H. (2005) The utility of neurophysiological markers in the study of alcoholism. Clin Neurophysiol 116, 9931018.
  • Robbins, T.W. (2005) Synthesizing schizophrenia: a bottom-up, symptomatic approach. Schizophr Bull 31, 85464.
  • Rybakowski, J.K., Borkowska, A., Skibinska, M. & Hauser, J. (2005) Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Mol Psychiatry. doi:10.1038/sj.mp.4001765
  • Sadler, J.Z. (2004) Values and Psychiatric Diagnosis. Oxford University Press, Oxford.
  • Schurov, I.L., Handford, E.J., Brandon, N.J. & Whiting, P.J. (2004) Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry 9, 11001110.
  • Seong, E., Seasholtz, A.F. & Burmeister, M. (2002) Mouse models for psychiatric disorders. Trends Genet 18, 643650.
  • Shields, J. & Gottesman, I.I. (1973) Genetic studies of schizophrenia as signposts to biochemistry. In Iversen, L.L. & Rose, S.P.R. (eds), Biochemistry and Mental Illness, Vol. 1. Biochemical Society, London, pp. 165174.
  • Siever, L.J. (2005) Endophenotypes in the personality disorders. Dialogues Clin Newosci 7, 139151.
  • Sing, C.F., Zerba, K.E. & Reilly, S.L. (1994) Traversing the biological complexity in the hierarchy between genome and CAD endpoints in the population at large. Clin Genet 46, 614.
  • Sing, C.F., Haviland, M.B. & Reilly, S.L. (1996) Genetic architecture of common multifactorial diseases. Ciba Found Symp 197, 211229; discussion 229–232.
  • Spedding, M., Jay, T., Costa e Silva, J. & Perret, L. (2005) A pathophysiological paradigm for the therapy of psychiatric disease. Nat Rev Drug Discov 4, 467476.
  • Swerdlow, N.R., Geyer, M.A. & Braff, D.L. (2001) Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) 156, 194215.
  • Tecott, L.H. (2003) The genes and brains of mice and men. Am J Psychiatry 160, 646656.
  • Waldman, I.D. (2005) Statistical approaches to complex phenotypes: evaluating neuropsychological endophenotypes for attention-deficit/hyperactivity disorder. Biol Psychiatry 57, 13471356.
  • Wang, X., Ishimori, N., Korstanje, R., Rollins, J. & Paigen, B. (2005) Identifying novel genes for atherosclerosis through mouse-human comparative genetics. Am J Hum Genet 77, 115.
  • Weinberger, D.R. (1995) From neuropathology to neurodevelopment. Lancet 346, 552557.
  • Weinberger, D.R., Egan, M.F., Bertolino, A., Callicott, J.H., Mattay, V.S., Lipska, B.K., Berman, K.F. & Goldberg, T.E. (2001) Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 50, 825844.
  • Yalcin, B., Willis-Owen, S.A., Fullerton, J., Meesaq, A., Deacon, R.M., Rawlins, J.N., Copley, R.R., Morris, A.P., Flint, J. & Mott, R. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36, 11971202.