SEARCH

SEARCH BY CITATION

References

  • Alvarez, V., Mata, I.F., Gonzalez, P., Lahoz, C.H., Martinez, C., Pena, J., Guisasola, L.M. & Coto, E. (2002) Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease. Am J Med Genet 114, 574577.
  • Ballerini, C., Nacmias, B., Rombola, G., Marcon, G., Massacesi, L. & Sorbi, S. (1999) HLA A2 allele is associated with age at onset of Alzheimer's disease. Ann Neurol 45, 397400.
  • Barcellos, L.F., Oksenberg, J.R., Begovich, A.B., Martin, E.R., Schmidt, S., Vittinghoff, E., Goodin, D.S., Pelletier, D., Lincoln, R.R., Bucher, P., Swerdlin, A., Pericak-Vance, M.A., Haines, J.L., Hauser, S.L. & Multiple Sclerosis Genetics Group. (2003) HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet 72, 710716.
  • Berr, C., Dufouil, C., Brousseau, T., Richard, F., Amouyel, P., Marceteau, E. & Alperovitch, A. (1996) Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: the EVA study. Neurosci Lett 218, 912.
  • Bi, X., Haque, T.S., Zhou, J., Skillman, A.G., Lin, B., Lee, C.E., Kuntz, I.D., Ellman, J.A. & Lynch, G. (2000) Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. J Neurochem 74, 14691477.
  • Bidere, N., Lorenzo, H.K., Carmona, S., Laforge, M., Harper, F., Dumont, C. & Senik, A. (2003) Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 278, 3140131411.
  • Brunk, U.T. & Terman, A. (2002) The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 269, 19962002.
  • Chung, H.Y., Kim, H.J., Kim, K.W., Choi, J.S. & B.P. (2002) Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech 59, 264272.
  • Dawkins, R., Leelayuwat, C., Gaudieri, S., Tay, G., Hui, J., Cattley, S., Martinez, P. & Kulski, J. (1999) Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease. Immunol Rev 167, 275304.
  • Dickson, D.W., Mattiace, L.A., Kure, K., Hutchins, K., Lyman, W.D. & Brosnan, C.F. (1991) Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab Invest 64, 135156.
  • Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., Goldman, D. & Weinberger, D.R. (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98, 69176922.
  • Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B. & Weinberger, D.R. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257269.
  • Fraser, C. & Stark, S. (2003) Cognitive symptoms and correlates of physical disability in individuals with multiple sclerosis. J Neurosci Nurs 35, 314320.
  • Gonzalez-Gay, M.A., Gonzalez-Juanatey, C. & Ollier, W.E. (2004) Endothelial dysfunction in rheumatoid arthritis: influence of HLA-DRB1 alleles. Autoimmun Rev 3, 301304.
  • Guerini, F.R., Ferrante, P., Losciale, L., Caputo, D., Lombardi, M.L., Pirozzi, G., Luongo, V., Sudomoina, M.A., Andreewski, T.V., Alekseenkov, A.D., Boiko, A.N., Gusev, E.I. & Favorova, O.O. (2003) Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. Neurology 61, 520526.
  • ‘t Hart, B.A., Brok, H.P., Amor, S. & Bontrop, R.E. (2001) The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels. Hum Immunol 62, 13711381.
  • Heim, A.W. (1970) AH4 Group Test of General Intelligence. NFER-Nelson, Windsor, U.K.
  • Ho, G.J., Drego, R., Hakimian, E. & Masliah, E. (2005) Mechanisms of cell signaling and inflammation in Alzeheimer's Disease. Curr Drug Targets Inflamm Allergy 4, 247256.
  • Joober, R., Gauthier, J., Lal, S., Bloom, D., Lalonde, P., Rouleau, G., Benkelfat, C. & Labelle, A. (2002) Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch Gen Psychiatry 59, 662663.
  • Liblau, R. & Gautam, A.M. (2000) HLA, molecular mimicry and multiple sclerosis. Rev Immunogenet 2, 95104.
  • Malhotra, A.K., Kestler, L.J., Mazzanti, C., Bates, J.A., Goldberg, T. & Goldman, D. (2002) A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159, 652654.
  • Mattiace, L.A., Davies, P. & Dickson, D.W. (1990) Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol 136, 11011114.
  • McDermott, J.R. & Gibson, A.M. (1996) Degradation of Alzheimer's beta-amyloid protein by human cathepsin D. Neuroreport 7, 21632166.
  • McGeer, P.L., Schulzer, M. & McGeer, E.G. (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47, 425432.
  • Menzer, G., Muller-Thomsen, T., Meins, W., Alberici, A., Binetti, G., Hock, C., Nitsch, R.M., Stoppe, G., Reiss, J. & Finckh, U. (2001) Non-replication of association between cathepsin D genotype and late onset Alzheimer disease. Am J Med Genet 105, 179182.
  • Nakanishi, H. (2003) Neuronal and microglial cathepsins in aging and age-related diseases. Ageing Res Rev 2, 367381.
  • Neill, D., Curran, M.D., Middleton, D., Mawhinney, H., Edwardson, J.A., McKeith, I., Ballard, C., Morris, C., Ince, P., Jaros, E. & Perry, R. (1999) Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03. Neurosci Lett 275, 137140.
  • Neumann, H. (2001) Control of glial immune function by neurons. Glia 36, 191199.
  • Ntais, C., Polycarpou, A. & Ioannidis, J.P. (2004) Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review. Am J Epidemiol 159, 527536.
  • Papassotiropoulos, A., Bagli, M., Feder, O., Jessen, F., Maier, W., Rao, M.L., Ludwig, M., Schwab, S.G. & Heun, R. (1999) Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease. Neurosci Lett 262, 171174.
  • Papassotiropoulos, A., Bagli, M., Kurz, A., Kornhuber, J., Forstl, H., Maier, W., Pauls, J., Lautenschlager, N. & Heun, R. (2000) A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease. Ann Neurol 47, 399403.
  • Papassotiropoulos, A., Lewis, H.D., Bagli, M., Jessen, F., Ptok, U., Schulte, A., Shearman, M.S. & Heun, R. (2002) Cerebrospinal fluid levels of beta-amyloid (42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene. Neuroreport 13, 12911294.
  • Payami, H., Schellenberg, G.D., Zareparsi, S., Kaye, J., Sexton, G.J., Head, M.A., Matsuyama, S.S., Jarvik, L.F., Miller, B., McManus, D.Q., Bird, T.D., Katzman, R., Heston, L., Norman, D. & Small, G.W. (1997) Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease. Neurology 49, 512518.
  • Payton, A., Holland, F., Diggle, P., Rabbitt, P., Horan, M., Davidson, Y., Gibbons, L., Worthington, J., Ollier, W.E.R. & Pendleton, N. (2003) Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Mol Psychiatry 8, 1418.
  • Pendleton, N., Payton, A., Van Den Boogerd, E.H., Holland, F., Diggle, P., Rabbitt, P.M., Horan, M.A., Worthington, J. & Ollier, W.E. (2002) Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neurosci Lett 324, 7476.
  • Peters, A., Rosene, D.L., Moss, M.B., Kemper, T.L., Abraham, C.R., Tigges, J. & Albert, M.S. (1996) Neurobiological bases of age-related cognitive decline in the rhesus monkey. J Neuropathol Exp Neurol 55, 861874.
  • Petkov, C.I., Wu, C.C., Eberling, J.L., Mungas, D., Zrelak, P.A., Yonelinas, A.P., Haan, M.N. & Jagust, W.J. (2004) Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities. J Int Neuropsychol Soc 10, 371381.
  • Rabbitt, P., Diggle, P., Horan, M., Pendleton, N., Bent, N., Abson, V., Jones, M. & McInnes, L. (2004) The University of Manchester Longitudinal Study of normal healthy old age 1983 through 2003. Aging Neuropsychol Cogn 11, 245279.
  • Rabbitt, P. & Lowe, C. (2000) Patterns of cognitive ageing. Psychol Res 63, 308316.
  • Raven, J.C. (1965) The Mill Hill Vocabulary Scale. H.K. Lewis, London.
  • Refolo, L.M. & Fillit, H.M. (2004) Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease. J Mol Neurosci 23, 151155.
  • Rogers, J., Kirby, L.C., Hempelman, S.R., Berry, D.L., McGeer, P.L., Kaszniak, A.W., Zalinski, J., Cofield, M., Mansukhani, L., Willson, P. & Kogan, F. (1993) Clinical trial of indomethacin in Alzheimer's disease. Neurology 43, 16091611.
  • Rybakowski, J.K., Borkowska, A., Czerski, P.M., Skibinska, M. & Hauser, J. (2003) Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 5, 468472.
  • Sadik, G., Kaji, H., Takeda, K., Yamagata, F., Kameoka, Y., Hashimoto, K., Miyanaga, K. & Shinoda, T. (1999) In vitro processing of amyloid precursor protein by cathepsin D. Int J Biochem Cell Biol 31, 13271337.
  • Savage, R.D. (1984) Alphabet Coding Task-15. Published by. Murdock University, Perth, W. Australia.
  • Schmidt, R., Schmidt, H., Curb, J.D., Masaki, K., White, L.R. & Launer, L.J. (2002) Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 52, 168174.
  • Shepherd, C.E., Piguet, O., Broe, G.A., Creasey, H., Waite, L.M., Brooks, W.S. & Kril, J.J. (2004) Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects. J Neuroimmunol 148, 178182.
  • Sloane, J.A., Hollander, W., Moss, M.B., Rosene, D.L. & Abraham, C.R. (1999) Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 20, 395405.
  • Small, B.J., Graves, A.B., McEvoy, C.L., Crawford, F.C., Mullan, M. & Mortimer, J.A. (2000) Is APOE epsilon4 a risk factor for cognitive impairment in normal aging? Neurology 54, 20822088.
  • Thomson, W., Barrett, J.H., Donn, R., Pepper, L., Kennedy, L.J., Ollier, W.E., Silman, A.J., Woo, P., Southwood, T. & British Paediatric Rheumatology Study Group. (2002) Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology 41, 11831189.
  • Touitou, I., Capony, F., Brouillet, J.P. & Rochefort, H. (1994) Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction- single strand conformational polymorphism analysis and possible consequences in cancer cells. Eur J Cancer 30A, 390394.
  • Tyynela, J., Sohar, I., Sleat, S., Rosalie, M.G., Donnelly, R.J. & Baumann, M. (2000) A mutation in the ovine Cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. EMBO J 19, 27862792.
  • Utermann, G., Langenbeck, U., Beisiege, 1, U. & Weber, W. (1980) Genetics of the apolipoprotein E system in man. Am J Hum Genet 32, 339347.
  • Vergelli, M., Kalbus, M., Rojo, S.C., Hemmer, B., Kalbacher, H., Tranquill, L., Beck, H., McFarland, H.F., De Mars, R., Long, E.O. & Martin, R. (1997) T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells. J Neuroimmunol 77, 195203.
  • Weatherby, S.J., Thomson, W., Pepper, L., Donn, R., Worthington, J., Mann, C.L., Davies, M.B., Fryer, A.A., Boggild, M.D., Young, C.A., Jones, P.W., Strange, R.C., Ollier, W.E. & Hawkins, C.P. (2001) HLA-DRB1 and disease outcome in multiple sclerosis. J Neurol 248, 304310.
  • Weaver, J.D., Huang, M.H., Albert, M., Harris, T., Rowe, J.W. & Seeman, T.E. (2002) Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 59, 371378.
  • Yaffe, K., Lindquist, K., Penninx, B.W., Simonsick, E.M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S. & Harris, T. (2003) Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 61, 7680.