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The following supplementary material is available for this article:

Table S1: Summary of BDNF SNPs analyzed and their position in relation to genome NCBI build34, and the exons for all isoforms described in HapMap

Table S2:P values for the comparison of BDNF plasma concentration depending on the genotype of SNPs within the BDNF gene for ED patients

Table S3:P values for the comparison of BDNF plasma concentration depending on the genotype of SNPs within the BDNF gene in 50 unaffected sibs

Table S4: FBAT of BDNF SNPs. Stratification of ED subtypes

Figure S1: Genomic structure of the BDNF gene, according to all isoforms obtained from NCBI b35 assembly and described in the HapMap data. Haploview LD plot for SNPs analyzed in samples of patients with ED. Monomorphic SNPs and SNPs with minor allele frequency less than 1% were excluded from the analysis and are not shown.

Figure S2: Box plot representing BDNF plasma levels for anorexia patients and for every SNP following the codominant, dominant and recessive models. The SNPs are ordered by genomic location of all genotypes for every SNP in the BDNF gene. The SNPs represented in blue are the ones for which mean BDNF plasma levels are statistically different depending on the genotype. &ast;Statistically significant after Bonferroni correction (P < 0.0010). A: major allele; a: minor allele.

Figure S3: Box plot representing BDNF plasma levels for bulimia patients and for every SNP following the codominant, dominant and recessive models. The SNPs are ordered by genomic location of all genotypes for every SNP in the BDNF gene. The SNPs represented in blue are the ones for which mean BDNF plasma levels are statistically different depending on the genotype. &ast;Statistically significant after Bonferroni correction (P < 0.0010). A: major allele; a: minor allele.

Figure S4: Box plot representing BDNF plasma levels for 50 unaffected sib pairs and for every SNP following the codominant, dominant and recessive models. The SNPs are ordered by genomic location of all genotypes for every SNP in the BDNF gene. The SNPs represented in blue are the ones for which mean BDNF plasma levels are statistically different depending on the genotype. &ast;Statistically significant after Bonferroni correction (P < 0.002). A: major allele; a: minor allele.

This material is available as part of the online article from http://www.blackwell-synergy.com/doi/abs/10.1111/j.1601-4183X.2007.00301.x

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FilenameFormatSizeDescription
GBB_301_sm_FigureS1.tif696KSupporting info item
GBB_301_sm_FigureS2.tif310KSupporting info item
GBB_301_sm_FigureS3.tif381KSupporting info item
GBB_301_sm_FigureS4.tif219KSupporting info item
GBB_301_sm_TableS1.doc87KSupporting info item
GBB_301_sm_TableS2.doc42KSupporting info item
GBB_301_sm_TableS3.doc35KSupporting info item
GBB_301_sm_TableS4.doc113KSupporting info item

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