The authors wish it to be known that, in their opinion, the first and the second authors should be regarded as joint first authors.
The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress
Article first published online: 7 FEB 2007
2007 Blackwell Publishing Ltd
Genes, Brain and Behavior
Volume 7, Issue 1, pages 14–19, February 2008
How to Cite
Wasserman, D., Sokolowski, M., Rozanov, V. and Wasserman, J. (2008), The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress. Genes, Brain and Behavior, 7: 14–19. doi: 10.1111/j.1601-183X.2007.00310.x
- Issue published online: 7 FEB 2007
- Article first published online: 7 FEB 2007
- Received 5 January 2007, revised 25 January 2007, accepted for publication 29 January 2007
- CRHR1 gene;
The risk of suicide, which causes about 1 million deaths each year, is considered to augment as the levels of stress increases. Dysregulation in the stress response of the hypothalamic-pituitary-adrenocortical (HPA) axis, involving the corticotrophin-releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males. Here we have analyzed single nucleotide polymorphisms (SNPs) in these genes, in family trios with suicide attempter offspring (n = 542), by using the transmission disequilibrium test both in a two-staged screening/replication sample design and in detailed reanalysis in the entire sample. Stratification based on the levels of lifetime stress showed reproducible association and linkage of an SNP in the CRHR1 gene (rs4792887) to suicide attempters exposed to low levels of stress (P = 0.002), among whom most males were depressed (P = 0.001). The identified allele may represent a part of the genetic susceptibility for suicidality by increasing HPA axis activity upon exposure to low levels of stress.