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References

  • Bates, G., Harper, P.S. & Jones, L. (2002) Huntington’s Disease, 3rd Edn. OUP, Oxford.
  • Bates, G.P. & Murphy, P.S.J. (2002) Mouse models of Huntington’s disease. In Bates, G., Harper, P. & Jones, L. (eds), Huntington’s Disease. OUP, Oxford, pp. 387426.
  • Beal, M.F. & Ferrante, R.J. (2004) Experimental therapeutics in transgenic mouse models of Huntington’s disease. Nat Rev Neurosci 5, 373384.
  • Benjamini, Y. & Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful appraoch to multiple testing. J R Statist Soc B 57, 289300.
  • Bolivar, V.J., Manley, K. & Messer, A. (2004) Early exploratory behavior abnormalities in R6/1 Huntington’s disease transgenic mice. Brain Res 1005, 2935.
  • Bolstad, B.M., Collin, F., Brettschneider, J., Simpson, K., Cope, L., Irizarry, R. & Speed, T.P. (2005) Quality assessment of Affymetrix GeneChip data. In Gentleman, R., Carey, V., Huber, W., Irizarry, R. & Dutoit, S. (eds), Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Springer, Heidelberg, pp. 3348.
  • Brakensiek, K., Langer, F., Kreipe, H. & Lehmann, U. (2005) Absence of p21CIP1, p27KIP1 and p57KIP2 methylation in MDS and AML. Leukemia Res 29, 13571360.
  • Brooks, S.P., Pask, T., Jones, L. & Dunnett, S.B. (2004a) Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests. Genes Brain Behav 3, 206215.
  • Brooks, S.P., Pask, T., Jones, L. & Dunnett, S.B. (2004b) Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests. Genes Brain Behav 3, 206215.
  • Canals, J.M., Pineda, J.R., Torres-Peraza, J.F., Bosch, M., Martin-Ibanez, R., Munoz, M.T., Mengod, G., Ernfors, P. & Alberch, J. (2004) Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington’s disease. J Neurosci 24, 77277739.
  • Carter, R.J., Lione, L.A., Humby, T., Mangiarini, L., Mahal, A., Bates, G.P., Dunnett, S.B. & Morton, A.J. (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington’s disease mutation. J Neurosci 19, 32483257.
  • Chan, E.Y.W., Luthi-Carter, R., Strand, A., Solano, S.M., Hanson, S.A., DeJohn, M.M., Kooperberg, C., Chase, K.O., DiFiglia, M., Young, A.B., Leavitt, B.R., Cha, J.-H.J., Aronin, N., Hayden, M.R. & Olson, J.M. (2002) Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington’s disease. Hum Mol Genet 11, 19391951.
  • Colomer, V., Engelender, S., Sharp, A.H., Duan, K., Cooper, J.K., Lanahan, A., Lyford, G., Worley, P. & Ross, C.A. (1997) Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Hum Mol Genet 6, 15191525.
  • Cui, L., Jeong, H., Borovecki, F., Parkhurst, C.N., Tanese, N. & Krainc, D. (2006) Transcriptional repression of PGC-1[alpha] by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127, 5969.
  • Davies, S.W., Turmaine, M., Cozens, B.A., DiFiglia, M., Sharp, A.H., Ross, C.A., Scherzinger, E., Wanker, E.E., Mangiarini, L. & Bates, G.P. (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537548.
  • Van Dellen, A., Blakemore, C., Deacon, R., York, D. & Hannan, A.J. (2000) Delaying the onset of Huntington’s in mice. Nature 404, 721722.
  • Desplats, P.A., Kass, K.E., Gilmartin, T., Stanwood, G.D., Woodward, E.L., Head, S.R., Sutcliffe, J.G. & Thomas, E.A. (2006) Selective deficits in the expression of striatal-enriched mRNAs in Huntington’s disease. J Neurochem 96, 743757.
  • Erck, C., MacLeod, R.A. & Wehland, J. (2003) Cloning and genomic organization of the TTL gene on mouse chromosome 2 and human chromosome 2q13. Cytogenet Genome Res 101, 4753.
  • Gauthier, L.R., Charrin, B.C., Borrell-Pages, M., Dompierre, J.P., Rangone, H., Cordelieres, F.P., De Mey, J., MacDonald, M.E., Lemann, V., Humbert, S. & Saudou, F. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118, 127138.
  • Gautier, L., Cope, L., Bolstad, B.M. & Irizarry, R.A. (2004) affy – analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307315.
  • Gray, J., Yeo, G.S.H., Cox, J.J., Morton, J., Adlam, A.-L.R., Keogh, J.M., Yanovski, J.A., El Gharbawy, A., Han, J.C., Tung, Y.C.L., Hodges, J.R., Raymond, F.L., O’Rahilly, S. & Farooqi, I.S. (2006) Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55, 33663371.
  • Hansson, O., Castilho, R.F., Korhonen, L., Lindholm, D., Bates, G.P. & Brundin, P. (2001) Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington’s disease is dependent on age and CAG repeat length. J Neurochem 78, 694703.
  • Harris, Z.L., Davis-Kaplan, S.R., Gitlin, J.D. & Kaplan, J. (2004) A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia. Blood 103, 46724673.
  • Hattori, M., Fujiyama, A., Taylor, T.D. et al. (2000) The DNA sequence of human chromosome 21. Nature 405, 311319.
  • Hernandez, R.E., Rikhof, H.A., Bachmann, R. & Moens, C.B. (2004) vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish. Development 131, 45114520.
  • Hersch, S.M. & Ferrante, R.J. (2004) Translating therapies for Huntington’s disease from genetic animal models to clinical trials. NeuroRx 1, 298306.
  • Hodges, A., Strand, A.D., Aragaki, A.K. et al. (2006) Regional and cellular gene expression changes in human Huntington’s disease brain. Hum Mol Genet 15, 965977.
  • Hye, A., Lynham, S., Thambisetty, M. et al. (2006) Proteome-based plasma biomarkers for Alzheimer’s disease. Brain 129, 30423050.
  • Irizarry, R.A., Hobbs, B., Collin, F., Beazer-Barclay, Y.D., Antonellis, K.J., Scherf, U. & Speed, T.P. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostat 4, 249264.
  • Joseph, B., Wallen-Mackenzie, A., Benoit, G., Murata, T., Joodmardi, E., Okret, S. & Perlmann, T. (2003) p57Kip2 cooperates with Nurr1 in developing dopamine cells. PNAS 100, 1561915624.
  • Kernie, S.G., Liebl, D.J. & Parada, L.F. (2000) BDNF regulates eating behavior and locomotor activity in mice. Embo J 19, 12901300.
  • Li, H., Li, S.H., Cheng, A.L., Mangiarini, L., Bates, G.P. & Li, X.J. (1999) Ultrastructural localization and progressive formation of neuropil aggregates in Huntington’s disease transgenic mice. HumMol Genet 8, 12271236.
  • Lin, M.T. & Beal, M.F. (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787795.
  • Lione, L.A., Carter, R.J., Hunt, M.J., Bates, G.P., Morton, A.J. & Dunnett, S.B. (1999) Selective discrimination learning impairments in mice expressing the human Huntington’s disease mutation. J Neurosci 19, 1042810437.
  • Luthi-Carter, R., Strand, A., Peters, N.L., Solano, S.M., Hollingsworth, Z.R., Menon, A.S., Frey, A.S., Spektor, B.S., Penney, E.B., Schilling, G., Ross, C.A., Borchelt, D.R., Tapscott, S.J., Young, A.B., Cha, J.H. & Olson, J.M. (2000) Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease. Hum Mol Genet 9, 12591271.
  • Luthi-Carter, R., Hanson, S.A., Strand, A.D., Bergstrom, D.A., Chun, W., Peters, N.L., Woods, A.M., Chan, E.Y., Kooperberg, C., Krainc, D., Young, A.B., Tapscott, S.J. & Olson, J.M. (2002a) Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Hum Mol Genet 11, 19111926.
  • Luthi-Carter, R., Strand, A.D., Hanson, S.A., Kooperberg, C., Schilling, G., La Spada, A.R., Merry, D.E., Young, A.B., Ross, C.A., Borchelt, D.R. & Olson, J.M. (2002b) Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington’s disease mouse models reveal context-independent effects. Hum Mol Genet 11, 19271937.
  • Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S.W. & Bates, G.P. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493506.
  • Mazarakis, N.K., Cybulska-Klosowicz, A., Grote, H., Pang, T., Van Dellen, A., Kossut, M., Blakemore, C. & Hannan, A.J. (2005) Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington’s disease mice. J Neurosci 25, 30593066.
  • Morton, A.J., Lagan, M.A., Skepper, J.N. & Dunnett, S.B. (2000) Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington’s disease mutation. J Neurocytol 29, 679702.
  • Morton, A.J., Hunt, M.J., Hodges, A.K., Lewis, P.D., Redfern, A.J., Dunnett, S.B. & Jones, L. (2005a) A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington’s disease. Eur J Neurosci 21, 855870.
  • Morton, A.J., Wood, N.I., Hastings, M.H., Hurelbrink, C., Barker, R.A. & Maywood, E.S. (2005b) Disintegration of the sleep-wake cycle and circadian timing in Huntington’s disease. J Neurosci 25, 157163.
  • Passador-Gurgel, G., Hsieh, W.-P., Hunt, P., Deighton, N. & Gibson, G. (2007) Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. Nat Genet 39, 264268.
  • Rabiner, C.A., Mains, R.E. & Eipper, B.A. (2005) Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist 11, 148160.
  • Rubinsztein, D.C. (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443, 780786.
  • Shiang, R., Thompson, L.M., Zhu, Y.-Z., Church, D.M., Fielder, T.J., Bocian, M., Winokur, S.T. & Wasmuth, J.J. (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78, 335342.
  • Smyth, G.K. (2004) Linear models and empirical Bayes methods for assessing differential expression in micorarray experiments. Stat Meth Genet Mol Biol 3, Article 3.
  • Spires, T.L., Grote, H.E., Varshney, N.K., Cordery, P.M., Van Dellen, A., Blakemore, C. & Hannan, A.J. (2004) Environmental enrichment rescues protein deficits in a mouse model of Huntington’s disease, indicating a possible disease mechanism. J Neurosci 24, 22702276.
  • Trueman, R.C., Brooks, S.P., Jones, L. & Dunnett, S.B. (2007) The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock-in mouse model of Huntington’s disease. Eur J Neurosci 25, 551558.
  • Vonsattel, J.P., Myers, R.H., Stevens, T.J., Ferrante, R.J., Bird, E.D. & Richardson, E.P. Jr. (1985) Neuropathological classification of Huntington’s disease. J Neuropathol Exp Neurol 44, 559577.
  • Yamashita, T., Hashiramoto, A., Haluzik, M., Mizukami, H., Beck, S., Norton, A., Kono, M., Tsuji, S., Daniotti, J.L., Werth, N., Sandhoff, R., Sandhoff, K. & Proia, R.L. (2003) Enhanced insulin sensitivity in mice lacking ganglioside GM3. PNAS 100, 34453449.
  • Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B.R., Goffredo, D., Conti, L., MacDonald, M.E., Friedlander, R.M., Silani, V., Hayden, M.R., Timmusk, T., Sipione, S. & Cattaneo, E. (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease. Science 293, 493498.
  • Zuccato, C., Tartari, M., Crotti, A., Goffredo, D., Valenza, M., Conti, L., Cataudella, T., Leavitt, B.R., Hayden, M.R., Timmusk, T., Rigamonti, D. & Cattaneo, E. (2003) Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 35, 7683.
  • Zucker, B., Luthi-Carter, R., Kama, J.A., Dunah, A.W., Stern, E.A., Fox, J.H., Standaert, D.G., Young, A.B. & Augood, S.J. (2005) Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington’s disease: neuronal selectivity and potential neuroprotective role of HAP1. Hum Mol Genet 14, 179189.