Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?

Authors

  • A. Thompson,

    1. Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands
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  • K. Boekhoorn,

    1. Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands
    2. Neurosignalisation Moleculaire et Cellulaire, INSERM U706, Institut du Fer a Moulin, Paris, France
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  • A.-M. Van Dam,

    1. Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, the Netherlands
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  • P. J. Lucassen

    Corresponding author
    1. Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands
      *P. J. Lucassen, Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, PO Box 94084, 1090 GB Amsterdam, the Netherlands. E-mail: lucassen@science.uva.nl
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*P. J. Lucassen, Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, PO Box 94084, 1090 GB Amsterdam, the Netherlands. E-mail: lucassen@science.uva.nl

Abstract

This review addresses the role of adult hippocampal neurogenesis and stem cells in some of the most common neurodegenerative disorders and their related animal models. We discuss recent literature in relation to Alzheimer’s disease and dementia, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, alcoholism, ischemia, epilepsy and major depression.

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