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Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms

  1. A. Takahashi1,2,
  2. A. Nishi1,2,
  3. A. Ishii1,2,
  4. T. Shiroishi2,3,
  5. T. Koide1,2,*

Article first published online: 8 JUL 2008

DOI: 10.1111/j.1601-183X.2008.00419.x

Issue

Genes, Brain and Behavior

Genes, Brain and Behavior

Volume 7, Issue 8, pages 849–858, November 2008

Additional Information

How to Cite

Takahashi, A., Nishi, A., Ishii, A., Shiroishi, T. and Koide, T. (2008), Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms. Genes, Brain and Behavior, 7: 849–858. doi: 10.1111/j.1601-183X.2008.00419.x

Author Information

  1. 1

    Mouse Genomics Resource Laboratory, National Institute of Genetics, Mishima, Shizuoka

  2. 2

    Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Hayama

  3. 3

    Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan

* *T. Koide, Mouse Genomics Resource Laboratory, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka-ken 411-8540, Japan. E-mail: tkoide@lab.nig.ac.jp

Publication History

  1. Issue published online: 24 NOV 2008
  2. Article first published online: 8 JUL 2008
  3. Received 23 January 2008, revised 23 June 2008, accepted for publication 25 June 2008

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Keywords:

  • Emotionality;
  • consomic mouse strains;
  • wild-derived MSM;
  • genetic mapping;
  • QTL

Consomic strains have recently attracted attention as an advantageous method to screen for genes related to developmental, physiological, and behavioral phenotypes. Recently, a new set of consomic strains was established from the Japanese wild-derived mouse strain MSM/Ms and C57BL/6JJcl. By analyzing the entire consomic panel, we were able to identify a number of chromosomes associated with anxiety-like behaviors in the open-field (OF) test, a light–dark box and an elevated plus maze. Detailed observation of the OF behavior allowed us to identify chromosomes associated with those ethological traits, such as stretch attend, rearing, and jumping. Repeated OF test trials have different meanings for animals, and we found that some chromosomes responded to only the first or second trial, while others were consistent across both trials. By examining both male and female mice, sex-dependent effects were found in several measurements. Principal component analysis of anxiety-like behaviors extracted five factors: ‘general locomotor activity’, ‘thigmotaxis’, ‘risk assessment’, ‘open-arm exploration’ and ‘autonomic emotionality’. We mapped chromosomes associated with these five factors of emotionality.

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