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Postnatal handling reverses social anxiety in serotonin receptor 1A knockout mice

  1. C. Zanettini1,
  2. V. Carola2,3,
  3. L. Lo Iacono2,5,
  4. A. Moles1,4,
  5. C. Gross2,
  6. F. R. D'Amato1,*

Article first published online: 8 AUG 2009

DOI: 10.1111/j.1601-183X.2009.00531.x

Issue

Genes, Brain and Behavior

Genes, Brain and Behavior

Volume 9, Issue 1, pages 26–32, February 2010

Additional Information

How to Cite

Zanettini, C., Carola, V., Lo Iacono, L., Moles, A., Gross, C. and D'Amato, F. R. (2010), Postnatal handling reverses social anxiety in serotonin receptor 1A knockout mice. Genes, Brain and Behavior, 9: 26–32. doi: 10.1111/j.1601-183X.2009.00531.x

Author Information

  1. 1

    CNR Institute of Neuroscience, Via del Fosso di Fiorano 64, 00143 Roma, Italy

  2. 2

    Mouse Biology Unit, EMBL, Via Ramarini 32, 00015 Monterotondo, Italy

  3. 3

    Santa Lucia Foundation, European Centre for Brain Research (CERC), Via del Fosso di Fiorano 64/65, 00143 Rome, Italy

  4. 4

    Genomnia srl, Milano, Italy

  5. 5

    Present address: Drug Discovery and Development Department, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy

* F. R. D'Amato, CNR Institute of Neuroscience, Via del Fosso di Fiorano 64, 00143 Roma, Italy. E-mail: francesca.damato@cnr.it

Publication History

  1. Issue published online: 28 JAN 2010
  2. Article first published online: 8 AUG 2009
  3. Received 24 April 2009, revised 13 July 2009, accepted for publication 2 August 2009

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References

  • Anisman, H., Zaharia M.D., Meaney, M.J. & Merali, Z. (1998) Do early-life events permanently alter behavioral and hormonal responses to stressors? Int J Dev Neurosci 16, 149–164.
  • Brodkin, E.S., Hagemann, A., Nemetski, S.M. & Silver, L.M. (2004) Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Res 1002, 151–157.
  • Brunelli, S.A. (2005) Selective breeding for an infant phenotype: rat pup ultrasonic vocalization (USV). Behav Genet 35, 53–65.
  • Burgdorf, J., Panksepp, J., Brudzynski S.M., Kroes, R. & Moskal, J.R. (2005) Breeding for 50-kHz positive affective vocalization in rats. Behav Genet 35, 67–72.
  • Cabib, S., Puglisi-Allegra, S. & D'Amato, F.R. (1993) Effects of postnatal stress on dopamine mesolimbic system responses to aversive experiences in adult life. Brain Res 604, 232–239.
  • Carola, V., D’Olimpio F., Brunamonti, E., Mangia, F. & Renzi, P. (2002) Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav Brain Res 134, 49–57.
  • Carola, V., Frazzetto, G. & Gross, C. (2006) Identifying interactions between genes and early environment in the mouse. Genes Brain Behav 5, 189–199.
  • Costantini, F. & D'Amato, F.R. (2006) Ultrasonic vocalizations in mice and rats: social context and functions. Acta Zoolog Sin 52, 619–633.
  • D'Amato, F.R. & Cabib, S. (1987) Chronic exposure to a novel odor increases pups' vocalizations, maternal care, and alters dopaminergic functioning in developing mice. Behav Neural Biol 48, 197–205.
  • D'Amato, F.R. & Cabib, S. (2000)
  • D'Amato, F.R., Cabib, S., Ventura, R. & Orsini, C. (1998) Long-term effects of post-natal manipulation on emotionality are prevented by maternal anxiolytic treatment in mice. Develop Psychobiol 32, 225–234.
  • D'Amato, F.R., Scalera, E., Sarli, C. & Moles, A. (2005) Pups call, mothers rush: does maternal responsiveness affect the amount of ultrasonic vocalizations in mouse pups? Behav Genet 35, 103–112. (Erratum: (2006) Behav Genet 36, 471).
  • Dichter, G.S., Brunelli, S.A. & Hofer, M.A. (1996) Elevated plus-maze behavior in adult offspring of selectively bred rats. Physiol Behav 60, 299–304.
  • Gross, C., Santarelli, L., Brunner, D., Zhuang, X. & Hen, R. (2000) Altered fear circuits in 5-HT(1A) receptor KO mice. Biol Psychiatry 48, 1157–1163.
  • Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., Santarelli, L., Beck, S. & Hen, R. (2002) Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416, 396–400.
  • Heisler, L.K., Chu, H.M., Brennan, T.J., Danao, J.A., Bajwa, P., Parsons, L.H. & Tecott, L.H. (1998) Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci USA 95, 15049–15054.
  • Holmes, A., Le Guisquet, A.M., Vogel, E., Millstein, R.A., Leman, S. & Belzung, C. (2005) Early life genetic, epigenetic and environmental factors shaping emotionality in rodents. Neurosci Biobehav Rev 29, 1335–1346.
  • Klemenhagen, K.C., Gordon, J.A., David, D.J., Hen, R. & Gross, C.T. (2006) Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology 31, 101–111.
  • Lo Iacono, L. & Gross, C. (2008) Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. J Neurosci 28, 6250–6257.
  • Meaney, M.J., Diorio, J., Francis, D., Weaver, S., Yau, J., Chapman, K. & Seckl, J.R. (2000) Postnatal handling increases the expression of cAMP-inducible transcription factors in the rat hippocampus: the effects of thyroid hormones and serotonin. J Neurosci 20, 3926–3935.
  • Millstein, R.A. & Holmes, A. (2007) Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev 31, 3–17.
  • Mitchell, J.B., Iny, L.J. & Meaney, M.J. (1990) The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus. Brain Res Dev Brain Res 55, 231–235.
  • Moles, A., Sarli, C., Bartolomucci, A. & D'Amato, F.R. (2008) Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice. Psychoneuroendocrinology 33, 462–470.
  • Parfitt, D.B., Levin, J.K., Saltstein, K.P., Klayman, A.S., Greer, L.M. & Helmreich, D.L. (2004) Differential early rearing environments can accentuate or attenuate the responses to stress in male C57BL/6 mice. Brain Res 1016, 111–118.
  • Parfitt, D.B., Walton, J.R., Corriveau, E.A. & Helmreich, D.L. (2007) Early life stress effects on adult stress-induced corticosterone secretion and anxiety-like behavior in the C57BL/6 mouse are not as robust as initially thought. Horm Behav 52, 417–426.
  • Parks, C.L., Robinson, P.S., Sibille, E., Shenk, T. & Toth, M. (1998) Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci USA 95, 10734–10739.
  • Pryce, C.R. & Feldon, J. (2003) Long-term neurobehavioral impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms. Neurosci Biobehav Rev 27, 57–71.
  • Ramboz, S., Oosting, R., Amara, D.A., Kung, H.F., Blier, P., Mendelsohn, M., Mann, J.J., Brunner, D. & Hen, R. (1998) Serotonin receptor 1A knockout: an animal model of anxietyrelated disorder. Proc Natl Acad Sci USA 95, 14476–14481.
  • Tsetsenis, T., Ma, X.H., Lo Iacono, L., Beck, S.G. & Gross, C. (2007) Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Nat Neurosci 10, 896–902.
  • Weller, A., Leguisamo, A.C., Towns, L., Ramboz, S., Bagiella, E., Hofer, M., Hen, R. & Brunner, D. (2003) Maternal effects in infant and adult phenotypes of 5HT1A and 5HT1B receptor knockout mice. Dev Psychobiol 42, 194–205.
  • Winslow, J.T., Hearn, E.F., Ferguson, J., Young, L.J., Matzuk, M.M. & Insel, T.R. (2000) Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse. Horm Behav 37, 145–155.
  • Zimmerberg, B., Kim, J.H., Davidson, A.N. & Rosenthal, A.J. (2003) Early deprivation alters the vocalization behavior of neonates directing maternal attention in a rat model of child neglect. Ann NY Acad Sci 1008, 308–313.
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