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Figure S1: Control experiment with pure L-DOPA/ benserazide treatment (20/4 mg/kg, Sigma-Aldrich, Sweden). (a) The mean horizontal locomotor activity of six MitoPark mice treated (arrow) with the pure drug combination at the age of 30 weeks; locomotor activity of two MitoPark mice treated with saline is shown as dashed line. (b) Mean horizontal and vertical activities of eight control littermate mice during the first hour after treatment with saline (four mice) or pure L-DOPA/benserazide cocktail (four mice). Locomotor results were tested with Student&apos;s t-test and statistically significant differences are indicated as follows: &ast;, P < 0.05; &ast;&ast;&ast;, P < 0.001.

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