MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease
Version of Record online: 7 OCT 2009
© 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd/International Behavioural and Neural Genetics Society
Genes, Brain and Behavior
Volume 9, Issue 2, pages 173–181, March 2010
How to Cite
Galter, D., Pernold, K., Yoshitake, T., Lindqvist, E., Hoffer, B., Kehr, J., Larsson, N.-G. and Olson, L. (2010), MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease. Genes, Brain and Behavior, 9: 173–181. doi: 10.1111/j.1601-183X.2009.00542.x
- Issue online: 10 MAR 2010
- Version of Record online: 7 OCT 2009
- Received 23 April 2009, revised 2 July 2009, 20 August 2009, 3 September 2009, 18 September 2009, 28 September 2009, accepted for publication 29 September 2009
Additional Supporting Information may be found in the online version of this article:
Figure S1: Control experiment with pure L-DOPA/ benserazide treatment (20/4 mg/kg, Sigma-Aldrich, Sweden). (a) The mean horizontal locomotor activity of six MitoPark mice treated (arrow) with the pure drug combination at the age of 30 weeks; locomotor activity of two MitoPark mice treated with saline is shown as dashed line. (b) Mean horizontal and vertical activities of eight control littermate mice during the first hour after treatment with saline (four mice) or pure L-DOPA/benserazide cocktail (four mice). Locomotor results were tested with Student's t-test and statistically significant differences are indicated as follows: *, P < 0.05; ***, P < 0.001.
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