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A genome-wide association study identifies multiple loci associated with mathematics ability and disability
Article first published online: 10 NOV 2009
DOI: 10.1111/j.1601-183X.2009.00553.x
© 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd/International Behavioural and Neural Genetics Society
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How to Cite
Docherty, S. J., Davis, O. S. P., Kovas, Y., Meaburn, E. L., Dale, P. S., Petrill, S. A., Schalkwyk, L. C. and Plomin, R. (2010), A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes, Brain and Behavior, 9: 234–247. doi: 10.1111/j.1601-183X.2009.00553.x
Corrections added after publication 16 December 2009. For details on the corrections, please refer to the addendum on page 247.
Publication History
- Issue published online: 10 MAR 2010
- Article first published online: 10 NOV 2009
- Received 1 July 2009, revised 8 September 2009, 13 October 2009, accepted for publication 2 November 2009
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Figure S1: QQ-plots for association of ancestry-informative regions with high/low mathematical ability in samples 1 and 2. Negative log base 10 P-values from a mixed-effects model likelihood ratio test are plotted against theoretical quantiles from the null distribution. The straight line at x = y represents the null distribution and the grey areas represent 95% bootstrapped confidence intervals on the null. P-values from (a) sample 1 and (b) sample 2 are plotted for the 784 SNPs represented on the Affymetrix 500K two-chip array set which are located within the 12 autosomal ancestry-informative regions identified by the Wellcome Trust Case Control Consortium as demonstrating strong geographical differentiation across the United Kingdom. The lack of association in these regions indicates no effect of population stratification in samples 1 or 2.
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