Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder
Version of Record online: 2 SEP 2011
© 2011 The Authors. Genes, Brain and Behavior © 2011 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society
Genes, Brain and Behavior
Volume 10, Issue 8, pages 852–861, November 2011
How to Cite
McCarthy, M. J., Nievergelt, C. M., Shekhtman, T., Kripke, D. F., Welsh, D. K. and Kelsoe, J. R. (2011), Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder. Genes, Brain and Behavior, 10: 852–861. doi: 10.1111/j.1601-183X.2011.00725.x
- Issue online: 8 NOV 2011
- Version of Record online: 2 SEP 2011
- Accepted manuscript online: 22 JUL 2011 12:00AM EST
- Received 19 January 2011, revised 4 April 2011, 3 June 2011 and 12 July 2011, accepted for publication 16 July 2011
Additional Supporting Information may be found in the online version of this article:
Table S1: Univariate association of 16 SNPs selected from seven circadian clock genes and Li response using Fisher's exact test. Allele frequencies for the minor allele (A1) are indicated for Li responders and Li nonresponders and nominal P-values (P) and odds ratios (OR) are shown. Uncorrected P < 0.05 was considered nominally statistically significant with 1 df for each analysis.
Table S2: Genes with known or suspected roles in the circadian clock were individually selected from an expression micoarray data set representing over 54 000 transcripts, measured in six LCLs from patients with BD. Expression for the indicated gene was detected by at least one probe. NR1D1 and PER3 were initially not detected by microarray but were readily detected by PCR primers directed toward these transcripts.
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