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Supporting Information

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Table S1: Univariate association of 16 SNPs selected from seven circadian clock genes and Li response using Fisher&apos;s exact test. Allele frequencies for the minor allele (A1) are indicated for Li responders and Li nonresponders and nominal P-values (P) and odds ratios (OR) are shown. Uncorrected P < 0.05 was considered nominally statistically significant with 1 df for each analysis.

Table S2: Genes with known or suspected roles in the circadian clock were individually selected from an expression micoarray data set representing over 54 000 transcripts, measured in six LCLs from patients with BD. Expression for the indicated gene was detected by at least one probe. NR1D1 and PER3 were initially not detected by microarray but were readily detected by PCR primers directed toward these transcripts.

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