Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome
Article first published online: 11 APR 2012
© 2012 The Authors. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society
Genes, Brain and Behavior
Volume 11, Issue 4, pages 444–451, June 2012
How to Cite
Paschou, P., Stylianopoulou, E., Karagiannidis, I., Rizzo, R., Tarnok, Z., Wolanczyk, T., Hebebrand, J., Nöthen, M. M., Lehmkuhl, G., Farkas, L., Nagy, P., Szymanska, U., Lykidis, D., Androutsos, C., Tsironi, V., Koumoula, A., Barta, C., Klidonas, S., Ypsilantis, P., Simopoulos, C., TSGeneSEE Consortium, Skavdis, G. and Grigoriou, M. (2012), Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. Genes, Brain and Behavior, 11: 444–451. doi: 10.1111/j.1601-183X.2012.00778.x
- Issue published online: 7 JUN 2012
- Article first published online: 11 APR 2012
- Accepted manuscript online: 21 MAR 2012 12:21PM EST
- Received 19 October 2011, revised 29 January 2012, 20 February 2012, and 28 February 2012, accepted for publication 3 March 2012
Additional Supporting Information may be found in the online version of this article:
Appendix S1: Comparative analysis of Lhx6 and Lhx8 expression in the developing and adult brain of mouse and rat-LHX6 and LHX8 genetic association study samples and methods.
Appendix S2: Members of the TSGeneSEE consortium.
Figure S1: Pairwise LD tests (r2) in our German, Hungarian, Italian, and Polish samples, for all studied SNPs in the LHX6 and the LHX8 genes.
Table S1: Phenotypic details of TSGeneSEE (Hungarian, Italian, and Polish), and German sample. Patient numbers are shown in parentheses.
Table S2: Selection of tSNPs at LHX6 and LHX8 using the HapMap CEPH European population as reference (http://hapmap.ncbi.nlm.nih.gov/). The r2 threshold for tSNP selection was set to 0.8. Variation at LHX6 and LHX8 was captured by the selected tSNPs with a mean r2of 0.942 and 0.988, respectively.
Table S3a: Transmission test for linkage disequilibrium in four different populations (total of 222 trios) for single markers tested at LHX6 and LHX8 genes (test implemented and P-values determined by Haploview).
Table S3b: Transmission test for linkage disequilibrium in joint analysis of four different populations (total of 222 trios) for single markers tested at LHX6 and LHX8 genes (test implemented and P-values determined by Haploview). The TSGeneSEE sample corresponds to the Hungarian, Italian, and Polish samples analyzed jointly.
Table S4: Transmission test for linkage disequilibrium in four different populations (total of 222 trios) for a three SNP haplotype around SNP rs3808901 at the LHX6 gene (test implemented and P values determined by Haploview). The TSGeneSEE sample corresponds to the Hungarian. Italian. and Polish samples analyzed jointly.
Table S5: Allele frequencies of studied SNPs at LHX6 and LHX8 in all studied populations. Position refers to Build 36 of the genome.
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer-reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
|GBB_778_sm_AS1_TS5.pdf||507K||Supporting info item|
|GBB_778_sm_AppendixS2.docx||16K||Supporting info item|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.