Translational behaviour-genetic studies of alcohol: are we there yet?
Article first published online: 10 MAY 2012
Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Genes, Brain and Behavior
Volume 11, Issue 4, pages 375–386, June 2012
How to Cite
Crabbe, J. C. (2012), Translational behaviour-genetic studies of alcohol: are we there yet?. Genes, Brain and Behavior, 11: 375–386. doi: 10.1111/j.1601-183X.2012.00798.x
- Issue published online: 7 JUN 2012
- Article first published online: 10 MAY 2012
- Accepted manuscript online: 17 APR 2012 10:45AM EST
- Received 22 December 2011, revised 6 April 2012, accepted for publication 10 April 2012
- Adverse consequences;
- genetic animal models;
In biomedical research, one key stage of translating basic science knowledge to clinical practice is the reconciliation of phenotypes employed for laboratory animal studies with those important for the clinical condition. Alcohol dependence (AD) is a prototypic complex genetic trait. There is a long history of behaviour-genetic studies of AD in both human subjects and various genetic animal models. This review assesses the state of the art in our understanding of the genetic contributions to AD. In particular, it primarily focuses on the phenotypes studied in mouse genetic animal models, comparing them to the aspects of the human condition they are intended to target. It identifies several features of AD where genetic animal models have been particularly useful, and tries to identify understudied areas where there is good promise for further genetic animal model work.