Supporting Information

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Figure S1: Open field, elevated plus maze and light-dark box. (a) In the open field, Myk/+/Agrn mice show reduced locomotor activity compared to Myk/+ mice. (b) In the elevated plus maze, Myk/+ mice show more entries to the open arm than +/+ mice and (c) total entries do not differ between genotypes. (d) Myk/+/Agrn mice show reduced head dips compared to Myk/+ mice (+/+ n = 18, Agrn/+ n = 17, Myk/+ n = 21, Myk/+/Agrn n = 15). (e) In the light–dark, locomotor activity does not differ between genotypes (+/+ n = 16, Agrn/+ n = 12, Myk/+ n = 15, Myk/+/Agrn n = 12). Data are presented as the mean ± SEM. &ast;&ast;&ast;P < 0.001 compared to +/+; &num;&num;&num;P < 0.001 compared to Myk/+.

Table S1: Behavioral phenotypes in genetic mouse models of mania

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