Genetic suppression of agrin reduces mania-like behavior in Na+, K+-ATPase α3 mutant mice
Version of Record online: 11 MAY 2012
© 2012 The Authors. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society
Genes, Brain and Behavior
Volume 11, Issue 4, pages 436–443, June 2012
How to Cite
Kirshenbaum, G. S., Clapcote, S. J., Petersen, J., Vilsen, B., Ralph, M. R. and Roder, J. C. (2012), Genetic suppression of agrin reduces mania-like behavior in Na+, K+-ATPase α3 mutant mice. Genes, Brain and Behavior, 11: 436–443. doi: 10.1111/j.1601-183X.2012.00800.x
- Issue online: 7 JUN 2012
- Version of Record online: 11 MAY 2012
- Accepted manuscript online: 20 APR 2012 10:58AM EST
- Received 19 January 2012, revised 23 February 2012 and 27 March 2012, accepted for publication 15 April 2012
Additional Supporting Information may be found in the online version of this article:
Figure S1: Open field, elevated plus maze and light-dark box. (a) In the open field, Myk/+/Agrn mice show reduced locomotor activity compared to Myk/+ mice. (b) In the elevated plus maze, Myk/+ mice show more entries to the open arm than +/+ mice and (c) total entries do not differ between genotypes. (d) Myk/+/Agrn mice show reduced head dips compared to Myk/+ mice (+/+ n = 18, Agrn/+ n = 17, Myk/+ n = 21, Myk/+/Agrn n = 15). (e) In the light–dark, locomotor activity does not differ between genotypes (+/+ n = 16, Agrn/+ n = 12, Myk/+ n = 15, Myk/+/Agrn n = 12). Data are presented as the mean ± SEM. ***P < 0.001 compared to +/+; ###P < 0.001 compared to Myk/+.
Table S1: Behavioral phenotypes in genetic mouse models of mania
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