Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis
Article first published online: 8 OCT 2012
© 2012 The Authors. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society
Genes, Brain and Behavior
Volume 11, Issue 7, page 888, October 2012
How to Cite
- Issue published online: 8 OCT 2012
- Article first published online: 8 OCT 2012
Vol. 11, Issue 5, 623–632, Article first published online: 2 MAY 2012
After publication, we identified a systematic genotyping error that affects the boundaries of two congenic lines reported in Table 1. Lines 1 and 4 should have been defined by a distal homozygous B6 genotype at 98.87 Mb (rs27102250) rather than 96.49 Mb (rs27056693). Line 4 should have been defined by a proximal homozygous B6 genotype at 86.82 Mb (rs13481139) rather than 87.81 Mb (rs29397485).
The newly defined boundaries do not alter the main conclusion of the paper, which was that the QTL for methamphetamine sensitivity is most likely driven by an epistatic interaction of two or more alleles within the congenic segment. However, the 2.38 Mb distal extension of Line 1 means that four additional genes that possess cis-acting expression QTLs should have been included in Table 2 (q < 0.05 for analysis of the congenic region): 1700001P01Rik (97.63 Mb; A/J > B6), Osbpl7 (96.91 Mb; A/J < B6), Copz2 (96.71 Mb; A/J < B6), and Pcgf2 (97.55 Mb; A/J > B6). We apologize for this minor error.