Obesity is associated with previous suicide attempts in bipolar disorder

Authors

  • Fabiano A. Gomes,

    1. Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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  • Márcia Kauer-Sant’Anna,

    1. Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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  • Pedro V. Magalhães,

    1. Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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  • Felice N. Jacka,

    1. Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Australia
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  • Seetal Dodd,

    1. Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Australia
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  • Clarissa S. Gama,

    1. Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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  • Ângelo Cunha,

    1. University Hospital, Universidade Federal de Santa Maria, Santa Maria, Brazil
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  • Michael Berk,

    1. Department of Clinical and Biomedical Sciences, University of Melbourne, Geelong, Australia
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  • Flávio Kapczinski

    Corresponding author
    1. Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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Professor Flávio Kapczinski, INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, 2350 CEP 90035-003, Porto Alegre, RS, Brazil.
Tel: +55 51 21018845;
Fax: +55 51 21018846;
E-mail: kapcz@terra.com.br

Abstract

Gomes FA, Kauer-Sant’Anna M, Magalhães PV, Jacka FN, Dodd S, Gama CS, Cunha Â, Berk M, Kapczinski F. Obesity is associated with previous suicide attempts in bipolar disorder.

Objective: There is a paucity of data about risk factors for suicide attempts in bipolar disorder. The aim of this study is to examine the association between suicide attempts and obesity in people with bipolar disorder.

Methods: Two hundred fifty-five DSM-IV out-patients with bipolar disorder were consecutively recruited from the Bipolar Disorder Program at Hospital das Clínicas de Porto Alegre and the University Hospital at the Universidade Federal de Santa Maria, Brazil. Diagnosis and clinical variables were assessed with Structured Clinical Interview for DSM-IV-axis I (SCID I) and Program structured protocol. History of suicide attempts was obtained from multiple information sources including patients, relatives and review of medical records. Patients with body mass index (BMI) ≥ 30 were classified as obese.

Results: Over 30% of the sample was obese and over 50% had a history of suicide attempt. In the multivariate model, obese patients were nearly twice (OR = 1.97, 95% CI: 1.06–3.69, p = 0.03) as likely to have a history of suicide attempt(s).

Conclusion: Our results emphasise the relevance of obesity as an associated factor of suicide attempts in bipolar disorder. Obesity may be seen as correlate of severity and as such, must be considered in the comprehensive management of bipolar patients.

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