Acute administration of GLP-1 receptor agonists induces hypolocomotion but not anxiety in mice

  1. M. Krass,
  2. K. Rünkorg,
  3. E. Vasar,
  4. V. Volke*

DOI: 10.1111/j.1601-5215.2012.00648.x

Additional Information

Author Information

  1. Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia

*Dr. Vallo Volke, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia. Tel. +372 7 374338, fax: +372 7 374332, E-mail: vallo.volke@ut.ee

Publication History

  1. Accepted manuscript online: 11 JAN 2012 11:16AM EST

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Keywords:

  • anxiety;
  • cortisol;
  • neuroendocrinology;
  • stress

Objective The aim of the current study was to compare the behavioral and hormonal effects of systemic (subcutaneous) treatment with glucaemically equipotent doses of exenatide and liraglutide in mice.

Methods The effects of GLP-1 receptor agonists were determined on anxiety level in the light-dark compartment test, the motor activity in automated activity cages and finally, the forced swimming test was performed.

Results Both exenatide (1-20 μg/kg) and liraglutide (200-1200 μg/kg) decreased the glucose levels up to 30 % in freely fed animals. In glucaemically equipotent doses the drugs induced very similar behavioural and hormonal effects: there was no change on anxiety level or immobility time, however, both drugs suppressed motor activity and increased corticosterone levels.

Conclusion We conclude that the two clinically approved GLP-1 receptor agonists induce very similar suppression of motor activity and stimulation of corticosterone release in mice.

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