The many faces of the genetics contribution to temporomandibular joint disorder
Article first published online: 11 JUL 2008
Copyright © 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Orthodontics & Craniofacial Research
Volume 11, Issue 3, pages 125–135, August 2008
How to Cite
Oakley, M. and Vieira, A. (2008), The many faces of the genetics contribution to temporomandibular joint disorder. Orthodontics & Craniofacial Research, 11: 125–135. doi: 10.1111/j.1601-6343.2008.00426.x
- Issue published online: 11 JUL 2008
- Article first published online: 11 JUL 2008
- Dates: Accepted 18 April 2008
- myofascial pain dysfunction syndrome;
- temporomandibular joint;
- temporomandibular joint dysfunction syndrome
Authors – Oakley M, Vieira AR
Objectives – Review the literature on candidate genes for temporomandibular joint disorder (TMD).
Setting and Sample Population – Literature review.
Materials and Methods – Two basic approaches were used to obtain literature in any language regarding genes and TMD. First, Medline, Embase, and Science Citation Index databases were searched using the keywords ‘temporomandibular joint disorder’ and ‘temporomandibular joint dysfunction’ for studies published from 1966 to 2007. Then, the references list of the studies obtained in the database was also considered.
Results – Candidate genes for TMD include genes for individual variations in pain perception, gender and ethnicity, proinflammatory cytokines, female hormones, breakdown of extracellular matrix, and syndromic forms of TMD.
Conclusion – Most of the studies on genetic variation contributing to TMD are approaching the disease mainly from an immune-inflammatory perspective. Recent investigations of the genetic variables which may predict identifiable levels of pain perception may uncover new approaches to our traditional treatment modalities for the chronic pain patient.