In Search of a Super Solution: Controlled Trial of Glycine-Glucose Oral Rehydration Solution in Infantile Diarrhoea


(D. M.) Kothari Centre of Gastroenterology CMRI 7/2 Diamond Harbour Road Calcutta 700027 India


ABSTRACT: In a double blind trial a glycine fortified oral glucose electrolyte solution was evaluated in a group of infants and small children (n = 25) with moderate to severe dehydration due to acute diarrhoea, and was compared with a matched control group (n = 26) receiving only glucose based oral rehydration solution. It is seen that the diarrhoea stool output, duration of diarrhoea, and volume of oral rehydration fluid required to achieve and maintain hydration are significantly lower in the group receiving glycine fortified glucose electrolyte solution. The possibility of developing an oral rehydration solution which could also act as an absorption promoting drug is discussed.